Cestex (epsiprantel) is an oral medication used to treat tapeworm infections in dogs and cats. It may be combined with other products used to treat hookworms, roundworms, etc. It is available as 12.5mg tablets. The usual dose for dogs is 2.5mg/pound by mouth as one dose. The usual dose for cats is 1.25mg/pound by mouth as one dose. The medication is not affected by food. (Sold per tablet)
Pfizer Animal Health
CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Cestex (epsiprantel) tablets are indicated for the removal of tapeworms in the cat (Dipylidium caninum and Taenia taeniaeformis) and dog (Dipylidium caninum and Taenia pisiformis).
DESCRIPTION: Cestex tablets are film-coated and contain 12.5 mg, 25 mg, 50 mg or 100 mg of epsiprantel per tablet.
Epsiprantel is an anthelmintic that is active as a single dose against the common tapeworms of cats and dogs. Epsiprantel has a molecular weight of 326 and is chemically 2-(cyclohexylcarbonyl)-4-oxo-1,2,3,4,6,7,8,12b-octahydropyrazino[2,1-a]benza-zepine.
Epsiprantel acts directly on the tapeworm. Since it is minimally absorbed following oral administration, epsiprantel remains at the site of action within the gastrointestinal tract. Due to digestive process, tapeworm fragments or proglottids may not be readily visible in the stool.
INDICATIONS: Cestex tablets are indicated for the removal of the following:
Feline cestodes: Dipylidium caninum and Taenia taeniaeformis
Canine cestodes: Dipylidium caninum and Taenia pisiformis
DOSAGE AND ADMINISTRATION: Cestex tablets should be administered orally.
The recommended dosage of epsiprantel is: cats, 1.25 mg/lb of body weight; dogs, 2.5 mg/lb of body weight. The following table may be used as a guide:
Body Weight Dose
Seven weeks old
up to 10 lb 12.5 mg
11-20 lb 25.0 mg
Body Weight Dose
Seven weeks old
up to 5 lb 12.5 mg
6-10 lb 25.0 mg
11-20 lb 50.0 mg
21-40 lb 100.0 mg
41-50 lb 125.0 mg
51-60 lb 150.0 mg
61-80 lb 200.0 mg
81-90 lb 225.0 mg
91-100 lb 250.0 mg
101+ lb 2.5 mg/lb, rounding up to next whole tablet combination
Fasting is not necessary or recommended.
Unless exposure to the infected intermediate hosts is controlled, reinfection is likely and retreatment may be required. In the case of D. caninum, an effective flea control program should be instituted.
SAFETY: Epsiprantel has been evaluated in cats at 5 times the recommended dose given once daily for 3 days with no adverse effects noted. In tolerance studies, epsiprantel produced minimal clinical signs in cats given 40 times the recommended dose once daily for 4 days.
Epsiprantel has been evaluated in 14-day repeat dose studies in dogs at 500 mg/kg (90 times recommended dosage) with no significant adverse results. No side effects were observed during the clinical field studies.
Epsiprantel is not a cholinesterase inhibitor. During the course of clinical field studies, Cestex was administered concurrently with diethylcarbamazine citrate (dogs only), anti-inflammatory agents, insecticides, and nematocides with no drug incompatibilities noted.
CONTRAINDICATIONS: There are no known contraindications to the use of this drug.
WARNINGS: For use in cats and dogs only. Safety of use in pregnant or breeding animals has not been determined. Keep out of reach of children. Not for use in humans.
PRECAUTION: Do not use in kittens or puppies less than 7 weeks of age.
STORAGE: Store at controlled room temperature 15°-30°C (59°-86°F).
How Supplied: Cestex tablets are film-coated and contain 12.5 mg, 25 mg, 50 mg or 100 mg of epsiprantel per tablet. Cestex is supplied as described below:
Concentration Cat lbs. Dog lbs. Number Tab/bottle
12.5 mg 10 5 50, 100
25.0 mg. 20 10 50,100
50.0 mg. -- 20 25,50
100.00 -- 40 25,50
NADA #140-893, Approved by FDA
Distributed by: Pfizer Animal Health, Exton, PA 19341, USA, Div. of Pfizer Inc, NY, NY 10017.
NAC No.: 36900881