Pharmacia & Upjohn
(progesterone)
NET CONTENTS
10 EAZI-BREED CIDR Cattle Inserts per bag
Each EAZI-BREED CIDR Cattle Insert contains 1.38 grams
of progesterone in molded silicone over a flexible nylon spine.
Attached to each EAZI-BREED CIDR Cattle Insert is a polyester tail.
Caution: Federal law prohibits extra-label use of this drug to enhance food and/or fiber production in animals.
DRUG FACTS:
Active Ingredient: Progesterone, 1.38 grams per EAZI-BREED CIDR Cattle Insert
Uses:
- Synchronization of estrus in suckled beef cows, and replacement beef and dairy heifers
- Advancement of first postpartum estrus in suckled beef cows
- Advancement of first pubertal estrus in replacement beef heifers
- Synchronization of the return to estrus in lactating dairy cows inseminated at the immediately preceding estrus
The EAZI-BREED CIDR Cattle Insert provides an exogenous
source of the hormone progesterone during the 7-day administration
period. Removal of the EAZI-BREED CIDR Cattle Insert on treatment day 7
results in a rapid fall in plasma progesterone levels, which results in
synchronization of estrus in those animals responding to treatment.
WARNINGS:
Human Warning: Avoid contact with
skin by wearing protective gloves when handling the inserts. Keep this
and all medications out of the reach of children.
Environmental Warning: Store
removed EAZI-BREED CIDR Cattle Inserts in a plastic bag or other
sealable container until they can be properly disposed in accordance
with applicable local, state and Federal regulations.
Residue Warning: Neither a
pre-slaughter withdrawal interval nor a milk discard time is required
when this product is used according to label directions.
DO NOT USE:
- in beef or dairy heifers of insufficient size or age
for breeding or in cattle with abnormal, immature or infected genital
tracts.
- in beef cows that are less than 20 days postpartum or
in lactating dairy cows less than 40 days postpartum. The sponsor has
not provided effectiveness and animal safety data for the use of this
product in beef cows that are less than 20 days postpartum or in
lactating dairy cows that are less than 40 days postpartum.
- the EAZI-BREED CIDR Cattle Insert in lactating dairy cows concurrently with LUTALYSE®
Sterile Solution or other prostaglandin products for synchronization of
the return to estrus. The concurrent use with prostaglandin products is
not approved in lactating dairy cows.
- an insert more than once. To prevent the potential
transmission of venereal and blood borne diseases the EAZI-BREED CIDR
Cattle Insert should be disposed after a single use.
WHEN USING THIS PRODUCT:
- For synchronization of estrus in suckled beef cows
and replacement beef and dairy heifers, advancement of first postpartum
estrus in suckled beef cows, and advancement of first pubertal estrus
in beef heifers, you must use the EAZI-BREED CIDR Cattle Insert
concurrently with an injection of 5 mL of LUTALYSE Sterile Solution
(equivalent to 5 mg/mL dinoprost) administered on day 6 of the 7 day
administration period to assure maximum effectiveness.
- For synchronizing the return to estrus in lactating dairy cows inseminated at the immediately preceding estrus, do not administer LUTALYSE Sterile Solution or other prostaglandin products as they will interrupt pregnancy that may have occurred.
- In animals that respond to treatment the onset of
estrus generally occurs within 1 to 3 days after removal of the
EAZI-BREED CIDR Cattle Insert.
- Intravaginal administration of EAZI-BREED CIDR Cattle Insert for periods greater than 7 days may result in reduced fertility.
YOU MAY NOTICE:
- Increased loss of EAZI-BREED CIDR Cattle Inserts in
animals housed under crowded conditions, especially in heifers. Avoid
crowded conditions during treatment as other cattle, particularly
heifers, may remove EAZI-BREED CIDR Cattle Inserts by pulling on the
tail of the EAZI-BREED CIDR Cattle Insert. If loss rates are high
re-evaluate insertion technique and cattle handling facilities.
- Clear, cloudy, yellow or bloody mucus on the outside
of EAZI-BREED CIDR Cattle Insert when removed from animals. The mucus
may have an offensive odor. This is a result of mild irritation to the
vaginal lining by the presence of the EAZI-BREED CIDR Cattle Insert,
and generally clears between the time of removal and insemination. Such
irritation does not affect fertility at inseminations following
treatment.
- Reduced pregnancy rates to inseminations conducted
immediately prior to administration of EAZI-BREED CIDR Cattle Inserts
used for synchronizing the return to estrus in lactating dairy cows.
DIRECTIONS:
Suckled Beef Cows, Replacement Beef and Dairy Heifers: For
synchronization of estrus in suckled beef cows and replacement beef and
dairy heifers, advancement of first postpartum estrus in suckled beef
cows, and advancement of first pubertal estrus in beef heifers:
- Administer one EAZI-BREED CIDR Cattle Insert per
animal for 7 days (for example, if administered on a Monday remove on
the following Monday).
- Inject 5 mL LUTALYSE Sterile Solution (equivalent to
5 mg/mL dinoprost) 1 day prior to EAZI-BREED CIDR Cattle Insert
removal, on day 6 of the 7 day administration period.
- Observe animals for signs of estrus on days 1 to 3
after removal of the EAZI-BREED CIDR Cattle Insert and inseminate
animals about 12 hours after onset of estrus.
Lactating Dairy Cows: For synchronization of the return to estrus in lactating dairy cows inseminated at the immediately preceding estrus:
- Administer one EAZI-BREED CIDR Cattle Insert per
animal 14 ± 1 days after insemination and remove the EAZI-BREED CIDR
Cattle Insert 7 days later (for example, if administered on a Monday
remove on the following Monday).
- Observe animals for signs of estrus on days 1 to 3
after removal of the EAZI-BREED CIDR Cattle Insert and inseminate
animals about 12 hours after onset of estrus.
- Reminder: do not administer
LUTALYSE Sterile Solution or other prostaglandin products to cows, as
this will interrupt pregnancy that may have occurred at the immediately
previous insemination.
Insertion:
1. Avoid contact with skin by wearing protective gloves when handling inserts.
2. Only use the specially designed EAZI-BREED CIDR Cattle Insert Applicator for administration.
3. Restrain cattle appropriately (head catch, squeeze chute, gate, etc.) prior to administration.
4. Wash the EAZI-BREED CIDR Cattle Insert Applicator in
a non-irritating antiseptic solution, and then lubricate the front
portion of the EAZI-BREED CIDR Cattle Insert Applicator with a
veterinary obstetrical lubricant.
5. Push the flexible tail end of the EAZI-BREED CIDR
Cattle Insert into the EAZI-BREED CIDR Cattle Insert Applicator taking
care to assure the tail is extending upward through the slot of the
EAZI-BREED CIDR Cattle Insert Applicator and is pointed toward the
handle.
6. Fold the wings of the EAZI-BREED CIDR Cattle Insert
to make it longer and continue to advance the EAZI-BREED CIDR Cattle
Insert into the applicator until it is fully seated. When fully seated
only the tips of the wings should protrude (one half inch) from the end
of the EAZI-BREED CIDR Cattle Insert Applicator (see Figure 1 below).
7. Lubricate the protruding tips of the wings of the EAZI-BREED CIDR Cattle Insert with veterinary obstetrical lubricant.
8. Lift the tail of the animal and clean the exterior of the vulva.
9. Open the lips of the vulva and gently place the
loaded EAZI-BREED CIDR Cattle Insert Applicator through the vulva. The
slot in the EAZI-BREED CIDR Cattle Insert Applicator should face
upwards (see Figure 2 below).
10. Once the loaded EAZI-BREED CIDR Cattle Insert
Applicator is past the vulva slope the EAZI-BREED CIDR Cattle Insert
Applicator slightly upwards (35-45° angle) by lowering the handle, and
then forward, without forcing, until the EAZI-BREED CIDR Cattle Insert
Applicator is fully inserted or resistance is felt (see Figure 3 below).
11. Squeeze the finger grips within the handle of the
EAZI-BREED CIDR Cattle Insert Applicator to deposit the EAZI-BREED CIDR
Cattle Insert in the anterior vagina (see Figure 4 below) and then pull
the EAZI-BREED CIDR Cattle Insert Applicator backwards to remove it
from the vagina.
12. With the EAZI-BREED CIDR Cattle Insert correctly
placed, with the wings open in the anterior portion of the vagina, the
tail of the EAZI-BREED CIDR Cattle Insert should be visible, pointing
downward from the vulva of the animal. Tails of EAZI-BREED CIDR Cattle
Inserts that protrude more than 2.5 inches from the vulva may be
clipped to minimize removal by other animals.
Removal:
1. Remove EAZI-BREED CIDR Cattle Inserts by pulling, gently but firmly, on the protruding polyester tail.
2. EAZI-BREED CIDR Cattle Inserts have been reported to
reverse direction within the vagina; therefore, if the polyester tail
of the insert is not visible on the day of removal, check the vagina to
determine if an insert is present.
Figure 1
Figure 2
Figure 3
Figure 4
OTHER INFORMATION:
Store below 86°F (30°C)
To report suspected adverse reactions or questions call Pfizer Animal Health at 1-800-366-5288.
NADA #141-200, Approved by FDA
Made in New Zealand
Distributed by: Pharmacia & Upjohn Company, Division of Pfizer Inc, New York, NY 10017
1421000
819 241 003
Inactive Ingredients: silicone rubber, nylon and polyester.
EAZI-BREED is a trademark and CIDR is a registered trademark of DEC International, NZ, Ltd.
LUTALYSE is a registered trademark of Pharmacia & Upjohn Company
39006604-04/06
NAC No.: 10490613
