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  Prednisone Tabs (RX)
Prednisone  (RX)
Prednisone (RX)


 
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Prednisone is a glucocorticoid. Glucocorticoids are adrenocortical steroids, both naturally occuring and synthetic, that are readily absorbed from the gastointestinal tract. Prednisoneis an antiinflammatory agent.

Item# Item Name Our Price Qty Add
71-PRED-S-5-30 Prednisone Oral Sol (RX) 5mg./ml. 30 ml.
$68.99
71-PRED-T-10-100 Prednisone Tabs (RX) 10mg. 100 ct.
$25.99
71-PRED-T-10-1000 Prednisone Tabs (RX) 10mg. 1000 ct.
$246.99
71-PRED-T-1-100 Prednisone Tabs (RX) 1mg. 100 ct.
$19.25
71-PRED-T-25-100 Prednisone Tabs (RX) 2.5mg. 100 ct.
$13.99
(Out of Stock)
71-PRED-T-20-100 Prednisone Tabs (RX) 20mg. 100 ct.
$25.49
71-PRED-T-20-1000 Prednisone Tabs (RX) 20mg. 1000 ct.
$225.49
71-PRED-T-50-100 Prednisone Tabs (RX) 50mg. 100 ct.
$40.49
(Out of Stock)
71-PRED-T-5-100 Prednisone Tabs (RX) 5mg. 100 ct.
$15.99
71-PRED-T-5-1000 Prednisone Tabs (RX) 5mg. 1000 ct.
$150.49
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Features:
Prednisone is a white to practically white, odorless, crystalline powder and has a molecular weight of 358.43. It melts at about 230C with some decomposition. Prednison is very slightly soluble in water, slightly soluble in alcohol, chloroform, dioxane, and methanol. Each tablet, or oral administration, contains 5 mg, 10 mg, 20 mg, or 50 mg prednisone.



Extended Information:
DESCRIPTION:
Prednisone is a glucocorticoid. Glucocorticoids are adrenocortical steroids, both naturally occuring and synthetic, that are readily absorbed from the gastointestinal tract. The formula for prednisone is C21H26O5. Chemically, it is 17,21-dihydroxypregna-1, 4-diene-3, 11, 20-trione and has the following structural formula:

/

Prednisone is a white to practically white, odorless, crystalline powder and has a molecular weight of 358.43. It melts at about 230C with some decomposition. Prednison is very slightly soluble in water, slightly soluble in alcohol, chloroform, dioxane, and methanol.
Each tablet, or oral administration, contains 5 mg, 10 mg, 20 mg, or 50 mg prednisone.

INACTIVE INGREDIENTS:
5 mg: anhydrous lactose, colloidal silicon dioxide, magnesium stearate, microcrystalline cellulose, sodium starch glycolate, and talc.
10 mg: anhydrous lactose, colloidal silicon dioxide, magnesium stearate, microcrystalline cellulose, sodium starch glycolate, and talc.
20 mg: anhydrous lactose, D&C Yellow No. 10 Aluminum Lake, FD&C Yellow No. 6 Aluminum Lake, magnesium stearate, microcrystalline cellulose, and sodium starch glycolate.
50 mg: anhydrous lactose, colloidal silicon dioxide, croscarmellose sodium, magnesium stearate, microcrystalline cellulose, sodium lauryl sulfate and talc.

CLINICAL PHARMACOLOGY:
Naturally occuring glucocorticoids (hydrocortisone and cortisone), which also have salt-retaining properties, are used as replacement therapy in adrenocortical deficiency states. Their synthetic analogs, such as prednicone, are primarily used for tehri potent anti-inflammatory effects in disorders of many organ systems.
Glucocorticoids, such as prednisone, cause profound and varied metabolic effects. In addition, tehy modify the body's immune response to diverse stimili.

INDICATIONS AND USAGE:
Prednisone tablets are indicated int eh following conditions:
Endocrine disorders: primary or secondary adrenocortical insufficiency (hydrocoritsone or cortisone is the first choice; synthetic analogs may be used in conjunction with mineralocorticoids where applicable; in infacy mineralocorticoid supplementation is of particular importance), congenital adrenal hyperplasia, nonsuppurative thyroids, hypercalcemia associated with cancer.
Rheumatic disorders: as adjunctive therapy for short-term administration (to tide teh patient over an acute episode or exacerbation) in; psoriatic arthritis; rheumatoid arthritis, including juvenile rheumatoid arthritis (selected cases may require low-dose maintenance therapy); ankylosing post-traumatic osteoarthritis; synovitis of osteoarthritis; epicondylitis.
Collagen diseases: during an exacerbation or as maintenance therapy in selected cases of: systemic lupus erythematosus, acute rheumatic carditis.
Durmatologic diseases: pemphigus, bullous dermatitis herpetiformis, severe erythema multiforme (Stevens-Johnson syndrome), exfoilative dermatitis, mycosis fungoides, severe seborheic dermatitis.
Allergic states: control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment; seasonal or perennial allergic rhinitis, serum sickness, bronchial asthma, contact dermatitis, atopic dermatitis, drug hypersensitivity reactions.
Ophthalmic diseases: severe acute and chronic allergic and inflammatory processes involving the eye and its adnexa, such as: allergic conjunctivitis, keratitis, allergic corneal marginal ulcers, herpes zoster ophthalmicus, iritis and iridocyclits, choriorentinitis, anterior segment inflammation, diffuse posterior uveitis and choroditis, optic neuritis, sympathetic ophthalmia.
Respiratory diseases: dymptomatic sarcoidosis, Loeffler's sydrome not manageable by other means, berylliosis, fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy, aspiration pneumonitis.
Hematologic disorders: Idiopathic thrombocytopenic purpura in adults, secondary thrombocytopenia in adults, acquired (autoimmune) hemolytic anemia, eythroblastopenis (RBC anemia), congenital (erythroid) hypoplastic anemia.
Neoplastic diseases: for palliative management of: leukemias and lymophomas in adults, acute leukemia of childhood.
Edematous states: to induce a diuresis or remission of proteinuria int he nphrotic syndrom, without uremia, of the idiopathic type of that due to lupus erythematosus.
Gastointestinal disease: to tide the patient over a critical period of the disease in: ulcerative colitis, regional enteritis.
Miscellaneous: tuberculous meingitis with subarachnoid block or impending block when used concurrently with appropriate antituberculous chemotherapy, trichinosis with neurologic or mycardial involvement.
In addition to the above indications, prednisone tablets are indicated for systemic dermatomyositis (polymyositis).

CONTRAINDICATIONS:
Prednisone tablets are contraindicated in systemic fungal infections.

WARNINGS:
In patients on corticosteroid therapy subjected to unusual stress, increased dosage of rapidly acting corticosteroids before, during and after the stressful situation is indicated.
Corticosteroids may mask some signs of infection and new infections may appear during their use. There may be decreased resistance and inability to localize infection when corticosteroids are used.
Prolonged use of corticosteroids may produce posterior subcapsular cataracts, glaucoma with possible damage to the optic nerves, and may enhance the establishment of secondary ocular infections due to fungi or viruses.
Average and large doses of hydrocortisone or cortisone can cause elevation of blood pressure, salt and water retention, and increased excreation of potassium. These effects are less likely to occur with the synthetic dervatives except when used in large doses. Dietary salt restriction and potassium supplementation may be necessary. All corticorsteroids increase calcium excretion.
While on coricorsteroid therapy, patients should not be vaccinated against smallpox. Other immunization procedures should not be undertaken in patients who are on corticosteroids, especially on high doses, because of possible hazards of neurological complications and lack of antibody response.
Persons who are on drugs that suppress the immune system are more susceptible to infections than healthy individuals. Chichenpox and measles, for example, can have a more serious or evn fatal course in non-immune children or adults on corticosteroids. In such children or adults who have not had these diseases, particular chare should be taken to avoid exposure. How the dose, route, and duration of corticosteroid administration affects teh risk of developing a disseminated infection is not known. The contribution of the underlying disease and/or prior corticosterois treatment to the risk is also not known. If exposed to chichenpox, prophylaxis with varicella-zoster immune globulin (VZIG) may be indicated. If exposed to measles, prophylaxis with pooled intravenous immunoglobulin (IG) may be indicated. (See the respective package inserts for complete VZIG and IG prescribing information.) If chickenpox develops, treatment with antiviral agents may be considered.
The use of prednisone tablets in active tuberculosis should be restricted to those cases of fulminating or disseminated tuberculosis in which the corticosteroid is used for the management of the disease in conjunction with an appropriate antituberculous regmen.
If corticosteroids are indicated in patients with latent tuberculosis or tuberculin reactivity, close observation is necessary as reactivation of hte disease may occur. During prolonged corticosteroid therapy, these patients should receive chemoprophylaxis.
Usage in Pregnancy: Since adequate human reproduction studies have not been done wiht corticosteroids, the use of these drugs in pregnancy, nursing mothers or women of childbearing potentioal requires that the possible benefits of the drug be weighed against the potential hazzards to teh mother and embryo or fetus. Infants born of mothers who have received substatial doses of corticosteroids during pregnancy should be carefully observed for signs of hypoadrenalism.

PRECAUTIONS:
General: Drug-induced, secondary adrenocortical insufficiency may be minimized by gradual reduction of dosage. This type of relative insufficiency may persist for months after discontinuation of therapy; therefore, in any situation of stress occuring during that period, hormone therapy should be reinstitued. Since mineralocorticoid secretion may be impaired, salt and/or a mineralocorticoid should be administered concurrently.
There is an enhanced effect of corticosteroids on patients with hypothyroidism and in those with cirrhosis.
Corticosteroids should be used cautiously in patients with ocular herpes simplex because of possible coneal perforation.
The lowest possible dose of corticosteroid should be used to control the condition under treatment, and when reduction in dosage is possible, the reduction should be gradual.
Psychic derangements may appear when corticosteroids are used, ranging from euphoria, incomnia, mood swings, personality changes, and severe depression, to frank psychotic manifestations. Also, existing emotional instabiltiy or phychotic tendencies may be aggravated by corticosteroids.
Asprin should be used cautiously in conjunction with corticosteroids in hypoprothrombinemia.
Steroids should be used with caution in: nonspecific ulcerative colitis, if there is a probability of impending perforation, abscess or other pyogenic infection; diverticulitis; fresh intestinal anastomosis; active or latent peptic ulcer; renal indefficiency; hypertension; osteoprosis; and myasthenia gravis.
Growth and development of infants and children on prolonged corticosteroid therapy should be carefully observed.

INformATION FOR PATIENTS:
Persons who are on immunosuppressant doses of corticosteroids shoudl be warned to avoid exposure to chickenpox or measles. Patients shoudl also be advised that if they are exposed, medical advice shoudl be sought without delay.

ADVERSE REACTIONS:
Fluid and electrolyte dusturbances: sodium retention, fluid retention, congestive heart failure in susceptible patients, potassium loss, hypkalemic alkalosis, hypertension.
Musculoskeletal: muscle weakness, steroid myopathy. loss of muscle mass, osteoporosis, vertebral compression fractures, aseptic necrosis of femoral and humeral heads, pathological fractures of long bones.
Gastrointestinal: peptic ulcer with possible perforation and hemorrhage, pancreatitis, abdominal distention, ulcerative esophagitis.
Dermatologic: impaired wound healing, thin fragile skin, petechiae and ecchymoses, facial erythema, increased sweating, may suppress reactions to skin tests.
Neurological: convulsions, increased intracranial pressure with papilledema (pseudotumor cerebri) usually after treatment, vertigo, headache.
Endocrine: menstrual irregularities; development of cushingoid state; suppression of growth in children; secondary adrenocortical and pituitary unresponsiveness, particularly in times of stress, as in trauma, surgery or illness; decreased carbohydrate tolerance; manifestations of latent diabetes mellitus; increased requirements for insulin or oral hypoglycemic agents in diabetics.
Ophthalmic:posterior subcapsular cataracts, increased intraocular pressure, glaucoma, exophthalmos.
Metabolic: negative nitrogen balance due to protein catabolism.

DOSAGE AND ADMINISTRATION:
Dosage of prednisone tablets should be individualized according to the severity of the disease and the response of the patient. For infants and childresn, the recommended dosage should be governed by the same considerations rather than strict adherence to the ratio indicated by age or body weight.
Hormone therapy is an adjunct to, and not a replacement for conventional therapy.
Dosage should be decreased or discontinued gradually when the drug has been administered for more than a few days.
The severity, prognosis, expected duration of the disease, and the reaction of the patient to the medication are primary factors of determining dosage.
If a period of spontaneous remission occurs in a chronic condition, treatment should be discontinued.
Blood pressure, body weight, routine laboratory studies, including two-hour postprandial blood glucose and serum potassium, and a chest X-ray shoudl be obtained at regular intervals during prolonged therapy. Upper GI X-rays are desirable in patients with known or suspected peptic ulcer disease.
The initial dosage of prednisone may vary from 5 mg to 60 mg per day, depending on the specific disease entity being treated. In situationsof less severity lower doses will generally suffice, while in selected patients higher initial doses may be required. The initial dosage shoudl be maintained or adjusted until a staisfactory response is noted. If after a reasonable period of time there is a loack of satisfactory clinical response, prednisone shoudl be discontinued and the patient transferred to other appropriate therapy. IT SHOULD BE EMPHASIZED THAT DOSAGE REQUIREMENTS ARE VARIABLE AND MUST BE INdivIDUALIZED ON THE BASIS OF THE DISEASE UNDER TREATMENT AND THE RESPONSE OF THE PATIENT. After a favorable response is noted, the proper mainenance dosage shoudl be determined by decreasing the initial drug dosage in small decrements at appropriate time intervals until the lowest dosage which will maintain an adequate clinical response is reached. It shoud be kept in mind that constant monitoring is needed in regard to drug dosage. Included in the situations which may make dosage adjustment necessary are changes in clinical status secondary to remiddions or exacerbations in the diesase process, the patient's individual drug responsiveness, and the effect of patient exposure to stressful situations not durectly related to the disease entity under treatment; in this latter situation it may be necessary to increase the dosage of prednisone for a period of time consistent with the patient's conditions. If after long-term therapy the drug is to be stopped, it is recommended that it be withdrawn gradually rather than abruptly.

HOW SUPPLIED:
Prednisone tablets USP, 5 mg: White, round tablets, scored on one side and "West-ward 475" debossed on the other side. Each tablet contains 5 mg of prednisone for oral administration.
Bottles of 100 tablets
Bottles of 1,000 tablets
Unit Dose Boxes of 100 tablets

Prednisone tablets USP, 10 mg: White, round tablets, scored on one side and "West-ward 473" debossed on the other sied. Each tablet contains 10 mg of prednisone for oral administration.
Bottles of 100 tablets
Bottles of 500 tablets
Bottles of 1,000 tablets
Unit Dose Boxes of 100 tablets

Prednisone tablets USP, 20 mg: Peach colored, round tablets, scroed on one side and "West-ward 477" debossed on the other side. Each tablet contains 20 mg of prednisone for oral administration.
Bottles of 100 tablets
Bottles of 500 tablets
Bottles of 1,000 tablets
Unit Dose Boxes of 100 tablets

Prednisone tablets USP, 50 mg: White, round, compressed, scroed, flat-faced beveled edged tablets imprinted "West-ward 481". Each tablet contains 50 mg of prednisone for oral administration.
Bottles of 100 tablets
Bottles of 1,000 tablets
Unti Dose BOxes of 100 tablets

Store at 20-25C (68-77F). Protect from light and moisture.
Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.




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