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Ivy Animal Health
CONTROLLED RELEASE IMPLANTS
ACTIVE DRUG INGREDIENT: Each COMPUDOSE®
silicone rubber implant contains 25.7 mg estradiol and is coated with
not less than 0.5 mg of oxytetracycline powder as a local antibacterial.
For subcutaneous ear implantation in steers and heifers only.
INDICATIONS: For increased rate of
weight gain in suckling and pastured growing steers; for improved feed
efficiency and increased rate of weight gain in confined steers and
heifers. Do not use in veal calves. Effectiveness and animal safety in
veal calves have not been established.
USE: COMPUDOSE Controlled Release
Implant will provide an effective daily dose of estradiol for at least
200 days. No additional effectiveness may be expected from reimplanting
in less than 200 days.
DIRECTIONS: Insert one implant under the skin of the ear as directed in this leaflet.
WHEN TO IMPLANT COMPUDOSE:
At castration or later
Pastured growing steers
At weaning or later
Finishing steers and heifers
At arrival in feedlot
WARNING: Keep out of reach of children.
A withdrawal period has not been
established for this product in pre-ruminating calves. Do not use in
calves to be processed for veal.
A COMPUDOSE®/ENCORE® Implanter must be used to implant cattle.
DIRECTIONS FOR IMPLANTATION:
Insert one implant under the skin of the ear.
1. Confine animal in a squeeze chute.
2. To reduce the possibility of infection and resulting
implant loss, hygienic and antiseptic procedures should be followed
during implantation. The ear should be clean and dry. The skin should be
cleansed with a suitable antiseptic soap and dried prior to implanting.
This is particularly important if the ears are contaminated with urine
3. To load the COMPUDOSE/ENCORE Implanter remove the
cartridge from the package, release the latch on the magazine, open and
insert the cartridge. (Figure 1)
Close the magazine and latch. Advance the cartridge
to the next implant by inserting the thumb into the magazine opening and
turning the cartridge to the next stop.
Use a sharp needle. The needle should be cleaned and
sterilized between each injection by wiping the exterior with a sponge,
cloth, or gauze saturated with an appropriate disinfectant. The presence
of excessive moisture inside the needle may result in dissolving the
oxytetracycline (OTC) from the implant surface and contribute to
accumulation of OTC inside the needle.
4. The implant should be deposited under the skin on the
back side of the middle third of the ear. It should be placed between
the skin and cartilage, avoiding major blood vessels.Grasping the
tip of the ear with one hand and the implanter in the other, penetrate
the skin in the outer third of the ear. (Figure 2)
IMPORTANT: Do not penetrate cartilage.
5. Upon penetration, the needle should be fully inserted
(Figure 3) between the skin and cartilage, avoiding major blood
vessels. Full insertion of the needle is important to maximize implant
6. Pull the needle back as the implant is being
deposited by squeezing the lever on the implanter grip. Figure 4 shows
the implant in proper position in the middle third of the ear where the
skin is tight.
7. After repeated use, sufficient oxytetracycline (OTC)
from the implant may accumulate inside the needle to impede implant
passage. Periodic removal of the needle from the device and washing it
in water will prevent such accumulation. Before reusing, the needle
should be disinfected and allowed to dry after shaking vigorously to
remove excess water or disinfectant.
8. If reimplantation is desired, it is not necessary to
remove the existing COMPUDOSE implant. Place the second implant at the
same level and parallel to, but not in contact with the existing implant
or place it in the unimplanted ear in accordance with paragraphs 1-7 of
CAUTION: To maximize implant retention:
A. Fully insert the needle.
B. Deposit the implant in the middle third of the ear where the skin is tight.
C. Do not deposit the implant where the skin is loose in the third of the ear closest to the head.
The needle has been scientifically designed to maximize
retention. When it becomes dull, use a new needle. If the needle is
resharpened, sharpen only the point.
Failure to follow antiseptic implanting procedures,
particularly when the ears are contaminated with fecal material, may
result in infection and excessive implant loss. Implanting cattle during
wet weather may increase infection and implant loss.
Carefully check the ears for implant loss approximately 4
weeks after implantation. If loss occurs, reimplant using recommended
CAUTION: Increased sexual activity
(bulling, riding and excitability) has been reported in animals
implanted with COMPUDOSE. Implanted animals should be observed for such
signs particularly during the first few days after implanting and
animals being excessively ridden (bullers) should be removed to prevent
physical injury. Vaginal and rectal prolapse have been reported in
heifers implanted with COMPUDOSE.
CAUTION: Do not use in animals intended for breeding purposes.
Side Effects: Udder development, swollen or enlarged vulva and high tailheads may be observed in implanted heifers.
How Supplied: COMPUDOSE Implants are supplied in cartridges of 20 implants each.
Questions or comments call 1-888-462-3493
NADA 118-123, Approved by FDA
Manufactured by a non-sterilizing process.
Compudose is a registered trademark of Ivy Animal Health, Inc.
Manufactured for VetLife by Ivy Laboratories, Overland Park, KS 66214, USA
VetLife and Ivy Laboratories are divisions of Ivy Animal Health, Inc.
01 64 01 02
NAC No.: 10330134