Sale Alert!

Check out our latest deals! NEOPARŽ


  Home > Breeder Direct > Prescriptions / RX > Prescriptions A - C > Prescriptions (C) >

Cystorelin GnRh
Cystorelin
Cystorelin


 
Rx Required  / Vet Prescription Form will be needed to send this item.
At Check Out, Please choose your method of submission for your Prescription Product.
Cystorelin GnRh, by Merial, is a Gonadorelin (GnRh) diacetate tetrahydrate in a sterile solution suitable for IM or IV administration. Indicated for the treatment of ovarian follicular cysts in dairy cattle.

Item# Item Name List Price Our Price Sale Price Qty Add
71-036102 Cystorelin GnRh 15 dose 30ml
$45.95
$39.99
$ 39.99 (Out of Stock)
71-007635 Cystorelin GnRh 5 dose 10ml
$19.95
$13.99
$ 13.99 (Out of Stock)
Check the items you wish to purchase, then click


Features:
For the treatment of cystic ovaries in cattle



Extended Information:

Cystorelin Rx , 5ds, 10 ml

CYSTORELINŽ
Rx
Merial
NADA 098-379, Approved by FDA
C-03004-R5
Item No. 82830201
(Gonadorelin Diacetate Tetrahydrate)
FOR INJECTION
For the treatment of cystic ovaries in cattle

CAUTION:
Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian.

DESCRIPTION:
CYSTORELINŽ is a sterile solution containing 50 micrograms of gonadorelin (GnRH) diacetate tetrahydrate per milliliter suitable for intramuscular or intravenous administration. Gonadorelin is a decapeptide composed of the sequence of amino acids-
5-oxoPro-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2-
a molecular weight of 1182.32 and empirical formula C55H75N17O13. The diacetate tetrahydrate ester has a molecular weight of 1374.48 and empirical formula C59H91N17O21.
Gonadorelin is the hypothalamic releasing factor responsible for the release of gonadotropins (e.g., LH, FSH) from the anterior pituitary. Synthetic gonadorelin is physiologically and chemically identical to the endogenous bovine hypothalamic releasing factor.

PHARMACOLOGY AND TOXICOLOGY:
Endogenous gonadorelin is synthesized and/or released from the hypothalamus during various stages of the bovine estrus cycle following appropiate neurogenic stimuli. It passes via the hypophyseal portal vessels, to the anterior pituitary to effect the release of gonadotropins (e.g. LH, FSH). Synthetic gonadorelin administered intravenously or intramuscularly also causes the release of endogenous LH or FSH from the anterior pituitary.
Gonadorelin diacetate tetrahydrate has been shown to be safe. The LD50 for mice and rats is greater than 60 mg/kg, and for dogs, greater than 600 mcg/kg, respectively. No untoward effects were noted among rats or dogs administered 120 mcg/kg/day or 72 mcg/kg/day intravenously for 15 days.
It has no adverse effects on heart rate, blood pressure, or EKG to unanesthetized dogs at 60 mcg/kg. In anesthetized dogs it did not produce depression of myorcardial or system hemodynamics or adversely affect coronary oxygen supply or myocardial oxygen requirements.
The intravenous administration of 60 mcg/kg/day of gonadorelin diacetate tetrahydrate to pregnant rats and rabbits during organogenesis did not cause embryotoxic or teratogenic effects.
The intramuscular administration of 1000 mcg to normally cycling dairy cattle had no effect on hematology or blood chemistry.
Further, CYSTORELIN does not cause irritation at the site of intramuscular administration in dogs. The dosage administered was 72 mcg/kg/day for seven (7) days.

INDICATIONS AND DOSAGE:
CYSTORELINŽ is indicated for the treatment of ovarian follicular cysts in dairy cattle. Ovarian cysts are non-ovulated follicles with incomplete luteinization which result in nymphomania or irregular estrus.
Historically, cystic ovaries have responded to an exogenous source of luteinizing hormone (LH) such as human chorionic gonadotropin. CYSTORELIN initiates release of endogenous LH to cause ovulation and luteinization.
The recommended intravenous or intramuscular dosage of CYSTORELIN is 100 mcg (2 mL) per cow.
Each mL of CYSTORELIN contains:

Gonadorelin diacetate tetrahydrate  50 mcg
Benzyl Alcohol                                  9 mg
Sodium Chloride                             7.47 mg
Water for Injection, U.S.P.                     q.s.


pH adjusted with potassium phosphate (monobasic and dibasic).

PRECAUTIONS:
Not for use in humans.
Keep this and all drugs out of reach of children.
The Material Safety Data Sheet (MSDS) contains more detailed occupational safety information. To report adverse effects in users, to obtain an MSDS, or for assistance call 1-888-637-4251.

KEEP REFRIGERATED:
2°-8°C (36°-46°F).

HOW SUPPLIED:
CYSTORELIN is available in a concentration of 50 mcg/mL pH adjusted with potassium phosphate (monobasic and dibasic).
CYSTORELIN is supplied in multi-dose vials containing 10 mL of sterile solution.




Share your knowledge of this product with other customers... Be the first to write a review

Browse for more products in the same category as this item:

Breeder Direct > Prescriptions / RX > Prescriptions A - C > Prescriptions (C)

Google+
Social Tab
Are you a fan of A to Z Vet Supply?
:like>
Hide Bar

Read our latest blog post...