Pfizer Animal Health
1% injectable solution for
cattle and swine
PRODUCT DESCRIPTION: Dectomax
injectable solution is a ready-to-use, colorless to pale yellow, sterile
solution containing 1% w/v doramectin (10 mg/mL). In cattle, Dectomax
is formulated to deliver the recommended dosage (200 mcg/kg of body
weight) when given by subcutaneous (SC) or intramuscular (IM) injection
at the rate of 1 mL/110 lb of body weight. In swine, Dectomax is
formulated to deliver the recommended dosage (300 mcg/kg of body weight)
when given by IM injection at the rate of 1 mL/75 lb of body weight.
Dectomax injectable solution is a highly active, broad-spectrum
parasiticide for parenteral administration to cattle and swine. It
contains doramectin, a novel fermentation-derived macrocyclic lactone
discovered by Pfizer Inc. Doramectin is isolated from fermentations of
selected strains derived from the soil organism Streptomyces
A primary mode of action of macrocyclic lactones is to
modulate chloride ion channel activity in the nervous system of
nematodes and arthropods. Macrocyclic lactones bind to receptors that
increase membrane permeability to chloride ions. This inhibits the
electrical activity of nerve cells in nematodes and muscle cells in
arthropods and causes paralysis and death of the parasites. In mammals,
the neuronal receptors to which macrocyclic lactones bind are localized
within the central nervous system (CNS), a site reached by only
negligible concentrations of doramectin.
One dose of Dectomax injectable solution effectively
treats and controls a wide range of roundworm and arthropod parasites
that impair the health and productivity of cattle and swine.
Studies have demonstrated the safety margin of Dectomax
injection in cattle and swine. In USA trials, no toxic signs were seen
in cattle given up to 25 times the recommended dose, or in swine given
up to 10 times the recommended dose. Studies also demonstrated safety in
neonatal calves and piglets treated with up to 3 times the recommended
dose. In males (bulls and boars) and females (cows and sows during
folliculogenesis, implantation, organogenesis, and through gestation), a
dose 3 times the recommended dose had no effect on breeding
PRODUCT INDICATIONS: Cattle: Dectomax injectable solution is indicated
for the treatment and control of the following harmful species of
gastrointestinal roundworms, lungworms, eyeworms, grubs (see
PRECAUTIONS), sucking lice (see PRECAUTIONS), and mange mites. Consult
your veterinarian for assistance in the diagnosis, treatment, and
control of parasitism.
Gastrointestinal Roundworms (adults and fourth stage
larvae) - Ostertagia ostertagi (including
inhibited larvae), O. lyrata, Haemonchus placei,
Trichostrongylus axei, T. colubriformis, T. longispicularis1, Cooperia oncophora, C.
punctata, C. surnabada (syn. mcmasteri),
Bunostomum phlebotomum1, Strongyloides papillosus1, Oesophagostomum radiatum, Trichuris spp.1
Lungworms (adults and fourth stage larvae) - Dictyocaulus viviparus
Eyeworms (adults) - Thelazia spp.
Grubs (parasitic stages) - Hypoderma
bovis, H. lineatum
Sucking Lice - Haematopinus
eurysternus, Linognathus vituli, Solenopotes capillatus
Mange Mites - Psoroptes bovis,
Dectomax injectable solution has been proved to
effectively control infections and to protect cattle from reinfection
with Cooperia oncophora and Haemonchus
placei for 14 days, Ostertagia ostertagi
for 21 days, and C. punctata, Oesophagostomum radiatum, and Dictyocaulus
viviparus for 28 days after treatment.
Swine: Dectomax injectable
solution is indicated for the treatment and control of the following
species of gastrointestinal roundworms, lungworms, kidney worms, sucking
lice (see PRECAUTIONS), and mange mites. Consult your veterinarian for
assistance in the diagnosis, treatment, and control of parasitism.
Gastrointestinal Roundworms (adults and fourth stage
larvae) - Ascaris suum, Oesophagostomum dentatum,
Oesophagostomum, quadrispinulatum1, Strongyloides ransomi1, Hyostrongylus rubidus1
Lungworms (adults) - Metastrongylus spp.
Kidney Worms (adults) - Stephanurus
Mange Mites (adults and immature stages) - Sarcoptes scabiei var. suis
Sucking Lice (adults and immature stages) - Haematopinus suis
Administer Dectomax injectable solution at the recommended dosage of
200 mcg doramectin per kg (91 mcg/lb) of body weight. Each mL contains
10 mg of doramectin, sufficient to treat 110 lb (50 kg) of body weight.
Body Weight (lb)
Swine: Administer Dectomax
injectable solution at the recommended dosage of 300 mcg doramectin per
kg (136 mcg/lb) of body weight. Each mL contains 10 mg of doramectin,
sufficient to treat 75 lb (34 kg) of body weight.
Body Weight (lb)
RECOMMENDED TREATMENT PROGRAM FOR
SWINE: To effectively initiate control of mange and sucking lice in
swine, it is important to treat all animals in the herd. After initial
treatment, use Dectomax regularly as follows:
Sows: Treat 7-14 days prior to
farrowing to minimize exposure of piglets to mites and sucking lice.
Gilts: Treat 7-14 days prior to
breeding. Treat 7-14 days prior to farrowing.
Boars: Treat a minimum of 2
times per year.
Feeder Pigs: Treat any new feeder
pigs upon arrival at farm or before placement in clean quarters.
Weaners, Growers, Finishers: Weaners
and grow-out/finisher pigs should be treated before placement in clean
For effective mange elimination, care must be taken to
prevent reinfestation from exposure to untreated animals or contaminated
ADMINISTRATION: Dry, sterile
equipment and aseptic procedures should be used when withdrawing and
administering Dectomax. For multiple treatments either automatic
injection equipment or an aspirating needle should be used.
Cattle: Administer Dectomax
injectable solution by the SC or IM route. Injections should be made
using a 16 gauge needle for adult cattle or an 18 gauge needle for young
animals. Needles 1/2-3/4” in length are suggested for SC
administration. A 1-1/2” needle is suggested for IM administration. SC
injections should be administered under the loose skin in front of or
behind the shoulder. IM injections should be administered into the
muscular region of the neck. Beef Quality Assurance guidelines recommend
SC administration as the preferred route.
Swine: Administer Dectomax
injectable solution by the IM route. Inject in the neck region using an
18 gauge x 1” needle for young animals; a 16 gauge x 1-1/2” needle for
sows and boars. To accurately meter doses administered to piglets, use
of a tuberculin syringe and 20 gauge x 1” needle is recommended.
WARNINGS: Not for human use. Keep out of
reach of children. The material safety data sheet (MSDS) contains more
detailed occupational safety information. To report adverse effects in
users, to obtain more information, or to obtain an MSDS, call
RESIDUE WARNINGS: Cattle: Do not slaughter for human consumption
within 35 days of treatment. Not for use in female dairy cattle 20
months of age or older. A withdrawal period has not been established for
this product in preruminating calves. Do not use in calves to be
processed for veal. Swine: Do not slaughter for
human consumption within 24 days of treatment.
PRECAUTIONS: Dectomax has been developed
specifically for use in cattle and swine only. This product should not
be used in other animal species as severe adverse reactions, including
fatalities in dogs, may result.
For SC injection in cattle only. For IM injection in
swine and cattle. This product is approved for the treatment and control
of sucking lice. For treatment of biting lice in cattle, use of
Dectomax Pour-On is recommended.
Dectomax is highly effective against all stages of
cattle grubs. However, proper timing of treatment is important. For most
effective results, cattle should be treated as soon as possible after
the end of the heel fly (warble) season.
Destruction of Hypoderma larvae
(cattle grubs) at the period when these grubs are in vital areas may
cause undesirable host-parasite reactions including the possibility of
fatalities. Killing H. lineatum when it is in
the tissue surrounding the gullet may cause bloat; killing H. bovis when it is in the vertebral canal may
cause staggering or paralysis. These reactions are not specific to
treatment with Dectomax, but can occur with any successful treatment of
grubs. Cattle should be treated either before or after these stages of
grub development. Consult your veterinarian concerning the proper time
Cattle treated with Dectomax after the end of the heel
fly season may be re-treated with Dectomax during the winter for
internal parasites, mange mites, or sucking lice, without danger of
grub-related reactions. A planned parasite control program is
ENVIRONMENTAL SAFETY: Studies
indicate that when doramectin comes in contact with the soil, it readily
and tightly binds to the soil and becomes inactive over time. Free
doramectin may adversely affect fish and certain aquatic organisms. Do
not permit water runoff from feedlots to enter streams or ponds. Do not
contaminate water by direct application or by the improper disposal of
drug containers. Dispose of containers in an approved landfill.
As with other avermectins, doramectin is excreted in the
dung of treated animals and can inhibit the reproduction and growth of
pest and beneficial insects that use dung as a source of food and for
reproduction. The magnitude and duration of such effects are species and
life-cycle specific. When used according to label directions, the
product is not expected to have an adverse impact on populations of
Store Below 30°C (86°F)
HOW SUPPLIED: Dectomax is available
in 100-mL, 200-mL, and 500-mL multi-dose, rubber-capped glass vials.
U.S. Patent No. 5,089,480
NADA #141-061, Approved by FDA
Consult your veterinarian for assistance in the
diagnosis, treatment, and control of parasitism.
Not for human use
Restricted Drug (CA) Use only as directed.
Laboratórios Pfizer Ltda. - Animal Health Division, Av.
Monteiro Lobato, 2270, Guarulhos, São Paulo, Brasil
CNPJ n° 46, 070,868/0001-69
Licenciado no Ministério da Agricultura sob o n°
4,055/92, em 14/08/92
Licensed in the Ministry of Agriculture under n°
4,055/92, on 08/14/92
Distributed by: Pfizer Animal
Health, Div. of Pfizer Inc, NY, NY 10017
Made in Brazil
NAC No.: 36900093