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Enterisol SC-54
Enterisol SC-54
Enterisol SC

For intranasal or water administration in healthy swine one day of age or older as an aid in the prevention of salmonellosis caused by Salmonella choleraesuis var kunzendorf. Contains 1 diluent and 1 vaccine.

Item# Item Name Our Price Qty Add
876-BISC50 Enterisol SC-54 50 dose 100ml
876-BISC5010 Enterisol SC-54 50 dose 100ml, 10 pack
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Extended Information:


Boehringer Ingelheim

Salmonella Choleraesuis Vaccine, Avirulent Live Culture

U.S. Patent No. 5,436,001

Read entire insert before use

Read the product label before use

Call Boehringer Ingelheim Vetmedica, Inc., Customer Service toll free at 1-800-325-9167 with any questions.

Indications: For intranasal or water administration in healthy swine one day of age or older as an aid in the prevention of salmonellosis caused by Salmonella choleraesuis var. kunzendorf.

Recommended for use only in healthy, susceptible swine, per label directions.


Administration & Dosage: Rehydrate the vaccine by adding the full contents of the accompanying sterile diluent to the vaccine vial. Shake well and use immediately. Rehydrate only with the diluent provided; do not mix with other materials.

Intranasal Vaccination: Fill syringe with reconstituted vaccine. Place cannula on the syringe tip and administer a single 2 mL dose intranasally to swine one day of age or older. Administer the complete 2 mL dose to each pig vaccinated. Efficacy and safety of the vaccine at other than the dose or routes prescribed on the label is unknown, and therefore, not recommended and not USDA approved.

Vaccination via the drinking water:

Conventional Water Directions (Open Trough or Barrel type (tank) System)

1. Do not open or mix vaccine until ready to vaccinate.

2. Remove all medications, sanitizers, and disinfectants from drinking water 72 hours (3 days) prior to vaccination.

3. Flush watering system with nonchlorinated/nontreated clean water to eliminate any antibacterial agents.

4. Rehydrate vaccine with accompanying diluent.

5. Add 2 mLs of rehydrated vaccine to the appropriate amount of clean, nontreated drinking water for each pig to be vaccinated (see table).

6. Final solution containing vaccine should be consumed within 4 hours after rehydration of vaccine.

Directions for Automatic Watering Systems equipped with proportioner: Several types of medicators/proportioners are commercially available.

1. Do not open or mix vaccine until ready to vaccinate.

2. Remove all medications, sanitizers, and disinfectants from drinking water 72 hours (3 days) prior to vaccination.

3. Provide sufficient watering space so that all pigs can drink within a 4-hour time frame.

4. Flush watering system with nontreated clean water to eliminate any antibacterial agents.

5. Set proportioner to deliver 1 oz. (30 mL) of vaccine solution per 1 gallon (4 liters) of water.

6. See Table to determine how many ounces of stock solution to prepare for pounds of pig to vaccinate.

7. Prepare vaccine concentrate as follows:

a. Rehydrate vaccine with accompanying diluent.

b. Add number of doses to container for stock solution equal to or more than number of pigs to vaccinate.

c. Add appropriate amount of clean, nontreated water to the container used for the stock solution.

d. Mix thoroughly.

8. Insert proportioner hose into vaccine concentrate and start water flow. Continue until all concentrate has been consumed before changing water supply to direct flow. Do not medicate or use disinfectants immediately following vaccination.

Incompatibility: All materials used in administration of this vaccine must be free of antibiotic and disinfectant residue to prevent inactivation and reduced product efficacy.

Storage Before Use: Store out of direct sunlight in the outer carton. Store at a temperature between 35°-45°F (2°-7°C). Do not freeze. Use entire contents when first opened. Do not use bottles of damaged product. Do not store reconstituted vaccine.

Total Weight of Group of Pigs
(# pigs x average pig weight)

Estimated water* consumption in 4-hour vaccination period

Oz. of stock solution needed to vaccinate lbs. of pigs in group. When run through proportioner set to deliver 1 oz. per gal.


.17 gallons

.17 oz.


.34 gallons

.34 oz.


.51 gallons

.51 oz.


.68 gallons

.68 oz.


.85 gallons

.85 oz.


1.02 gallons

1.02 oz.


1.19 gallons

1.19 oz.


1.36 gallons

1.36 oz.


1.53 gallons

1.53 oz.


1.70 gallons

1.70 oz.

*Based on .17 gallon consumed (21.8 oz.) per 100 pounds body weight in 4-hour period.

**Values for pigs 40 pounds or bigger

Caution: Pigs will generally drink 8-12% of their body weight per day depending on environmental temperatures. The actual amount of water consumed may vary considerable depending on several factors including environmental temperature.

Withdrawal Period: Vaccinated pigs are not to be harvested for human consumption before 21 days after vaccination.

Disposal: After use, burn containers and all unused contents by a procedure allowed by local, state, and federal regulations.

Expiration Date: Consult the outer carton for the last date the package of vaccine is acceptable for use.

Precautions: For veterinary use only

Avoid direct contact; If human exposure occurs, flush area with clean water, administer first aid, and consult physician immediately.

Anaphylactoid reactions may occur; Administer epinephrine.

Additional Information For Veterinarians: Many factors must be considered in determining a sound Salmonella choleraesuis vaccination program for a particular farm. To be most effective, the vaccine must be administered properly to healthy animals maintained in a proper environment under good management. Stressed or immunosuppressed pigs should not be vaccinated as the efficacy of the vaccine in these animals is unknown. The level of individual animal and herd immunity required will vary with management practices, the degree of exposure to salmonella, and the level of susceptibility of each animal. The vaccination program must be carefully planned and implemented in collaboration with the herd veterinarian following label and insert indications and precautions.

Pigs vaccinated intranasally at 3 weeks of age demonstrated a duration of immunity through at least 20 weeks post vaccination. The duration of immunity for pigs vaccinated intranasally at less than 3 weeks of age has not been determined.

Two field studies were conducted representing more than 50,000 total pigs. Non-vaccinated pigs and pigs vaccinated per label instructions via the drinking water when placed in the finishing barn (approximately 60 pounds body weight) were compared for prevalence of salmonella at slaughter. Contrasted with non-vaccinated pigs, vaccinated pigs had a significantly (p <0.05) lower prevalence of salmonella detected by culture of ileocecal lymph nodes collected at slaughter. In a clinical challenge study, pigs vaccinated intranasally with Enterisol® SC-54 (n=20) and non-vaccinated controls (n=10) were challenged with virulent Salmonella typhimurium 2 weeks post vaccination. During the subsequent 14 days the challenge control pigs shed S. typhimurium, which was isolated from 18.0% of daily fecal samples from individual study pigs. Vaccination with Enterisol® SC-54 significantly (p<0.05) reduced fecal shedding of S. typhimurium. Only 7.5% of fecal samples from vaccinates were culture positive, a 2.4 fold reduction versus non-vaccinated controls.

Previous or active Salmonella or other infection: The effect of concurrent or previous infections at or around the time of vaccination on the efficacy of this vaccine in reducing or modifying salmonellosis in pigs is not known.

How Supplied: Salmonella Choleraesuis Vaccine, Avirulent Live Culture is supplied in 50 dose cartons containing the lyophilized vaccine in amber glass with 100 mL of sterile diluent.

Boehringer Ingelheim Vetmedica, Inc., St. Joseph, MO 64506 USA


U.S. Veterinary License No. 124

472303N-03, 472301N-01

NAC No.: 10280432

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