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CHEMISTRY:Chemically the active
pharmaceutical ingredient in Equidone® Oral Gel is domperidone:
DOSAGE:Please follow the dosing
instructions of a licensed veterinarian.
DOSAGE GUIDELINES:Fescue Toxicosis and
Related Agalactia :Equidone® (domperidone) has been used at a dose of 1.1 mg/kg
(0.5 mg/lb) body weight once daily (PO SID) beginning 10-15 days after
foaling. In the event that fescue toxicosis and/or related agalactia was
diagnosed at less than 10 days prior to the expected foaling date
dosing was begun immediately continuing until 5-10 days after foaling.
On farms with a history of severe fescue toxicosis problems and where
mares remain on toxic fescue up to foaling dosing has been initiated as
early as 15-30 days prior to the expected foaling date continuing until
5-10 days after foaling.Post-Partum Agalactia: For
mares that have foaled but are agalactic or have a low level of milk
flow Equidone® (domperidone) has been used at a dose of 1.1 mg/kg (0.5
mg/lb) body weight twice daily (PO BID) for 3-5 days and once daily (PO
SID) for the next 5-7 days for a total of 10 days of treatment. Also
Equidone® (domperidone) has been used to treat agalactia in other
mammals. Follicular Growth: For mares that
are not developing ovulatory size follicles during the normal breeding
season Equidone® (domperidone) has been used at a dose of 1.1 mg/kg (0.5
mg/lb) body weight once daily (PO SID) until ovulation (usually 8-15
days). Follicular Growth (Transitional Mares):
Equidone® (domperidone) has been used to promote follicular growth in
transitional mares. Mares were initially placed under lights for two (2)
weeks. Mares were continued under lights and Equidone® (domperidone)
was administered at a done of 1.1 mg/kg (0.5 mg/lb) body weight once
daily (PO SID) until ovulation occurred. In once study mares maintained
outside under cold winter conditions did not respond well to this
regimen. Current research suggests that in cold winter conditions mares
kept inside respond better to treatment.
ADMINISTRATION:Note: The gel syringe is a multi-dose
package. Ensure that the correct dose if administered with each use.
Determine the correct weight of the mare. STEP 2: Using the correct
weight of the mare determine the appropriate dose [1 cc/100kg body
weight (1cc/220lbs body weight)]. The appropriate dose for a mare
weighing 500 kg (1 100 lbs.) is 5 cc. The following table may be used to
assist in determining the appropriate dose:
STEP 3: To measure
the dose turn the dosage ring (located on the plunger of the syringe)
until he edge of the dosing ring nearest to the syringe tip lines up
with the dose to be delivered.STEP 4: Ensure that the mare&146;s
mouth is free of food and/or other obstructions.STEP 5: Remove the
end cap from the tip of the syringe barrel.STEP 6: The selected dose
of gel should be deposited on the back and top of the mare’s tongue.
Introduce the tip of the syringe into the side of the mare’s mouth at
the interdental space between the front (incisor) and back (molar)
teeth. Deposit the gel on the mare’s tongue by dosage ring permits.
Remove the tip of the syringe from the horse’s mouth.STEP 7: To aid
in the swallowing of the get immediately raise the mare’s head for a few
seconds after dosing. STEP 8: Clean the tip of the syringe with a
clean disposable towel. Recap the syringe by returning the end cap to
the tip fo the syringe barrel and applying pressure until at least one
"click" is heard.STEP 9: For the next daily dose repeat steps 1-8.
CONTRAINDICATIONS:Equidone® (domperidone) has gastroprokinetic
effects and should not be used whenever stimulation of
gastric motility would be contraindicated (e.g. in the presence of
gastrointestinal hemorrhage mechanical obstruction or perforation).
WARNINGS:For use in animals only. Do not use in animals intended for
human consumption. Not for human use. Keep out of reach of children.
PRECAUTIONS:In certain instances of Equidone® (domperidone) use
pre-mature leaking of milk and/or colostrum may occur. If leaking
should occur and foaling does not occur within 24 hours administer
one-half (1/2) of the recommended dose twice daily at 12 hour intervals
(PO BID) and continue through 5 days after foaling. If leaking continues
administer one-third (1/3) of the recommended dose twice daily at 12
hour intervals (PO BID) and continue through 5 days after foaling. In
some cases therapy may need to be reduced to very low levels or
discontinued altogether. Please contact your licensed veterinarian for
more information.If excessive leaking of milk occurs foals should be
tested for serum Immunoglobulin G (lgG) levels. Foals with sub-par
serum lgG levels should be treated by your licensed veterinarian.Use
of Equidone® (domperidone) with concomitant therapies in mares has not
CLINICAL PHARMACOLOGY:Animals that consume endophyte (Neotyphodium
coenophialum) — infected fescue seed grass and/or hay generally manifest
signs of fescue toxicosis and consistently exhibit in
endophyte-infected fescue have been identified as probably causative
agents of fescue toxicosis. On the basis of these observations an in
vitro bioassay was developed to study the effects of individual
alkaloids produced by the endophyte on prolactin release; to D-2
dopamine receptor level; and to compare the efficacy of two selective
D-2 dopamine receptor antagonists domperidone and sulpiride in reversing
the inhibitory effect of α-ergocryptine (10-8 M) in
prolactin release. However at a similar concentration the dose-response
curve for sulpiride (quadratic fit) did not obtain a threshold
concentration for reversal of the effect of α-ergocryptine (10-8
M) in prolactin release.
STORAGE INformATION:Store at Controlled Room Temperature 15°-30° C
(59°-86° F). Do not freeze or expose to extremes of temperature.