Each mL contains
200 mg of oxytetracycline base as oxytetracycline dihydrate.
For use in beef
cattle; dairy cattle; calves, including preruminating (veal) calves; and
For animal use only
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Insert Carefully Before Using This Product
Liquamycin LA-200 (oxytetracycline
injection) is a sterile, ready-to-use solution for the administration of
broad-spectrum antibiotic oxytetracycline (Terramycin®) by
Terramycin, discovered by Pfizer scientists, is an antimicrobial agent
effective in the treatment of a wide range of diseases caused by
gram-positive and gram-negative bacteria.
administered to cattle or swine for the treatment of bacterial pneumonia
dosage of 9 mg of oxytetracycline per lb of body weight has been
clinical trials to be as effective as 2 or 3 repeated, daily treatments
Terramycin® Injectable at 3-5 mg/lb of body weight.
Liquamycin LA-200 does
not require refrigeration; however, it is recommended that it be stored
temperature, 15°-30°C (59°-86°F). The antibiotic activity of
not appreciably diminished in the presence of body fluids, serum, or
When administered to cattle, muscle
discoloration may necessitate trimming of the injection site(s) and
tissues during the dressing procedure.
treatment at least 28 days prior to slaughter of cattle and swine.
taken from animals during treatment and for 96 hours after the last
treatment must not be used for food. Rapid intravenous
result in animal collapse. Oxytetracycline should be administered
intravenously slowly over a period of at least 5 minutes.
Exceeding the highest recommended level
of drug per lb of body weight per day, administering more than the
number of treatments, and/or exceeding 10 mL subcutaneously per
in adult beef cattle and dairy cattle, and 5 mL intramuscularly per
site in adult swine, may result in antibiotic residues beyond the
Consult with your
veterinarian prior to administering this product in order to determine
proper treatment required in the event of an adverse reaction. At the
of any adverse reaction, discontinue use of the product and seek the
your veterinarian. Some of the reactions may be attributed either to
(an allergic reaction) or to cardiovascular collapse of unknown cause.
injection, treated animals may have transient hemoglobinuria resulting
As with all antibiotic
preparations, use of this drug may result in overgrowth of
organisms, including fungi. A lack of response by the treated animal, or
development of new signs, may suggest that an overgrowth of
organisms has occurred. If any of these conditions occur, consult your
drugs may interfere with the bactericidal action of penicillin, it is
to avoid giving Liquamycin LA-200 in conjunction with penicillin.
Reports of adverse reactions associated with oxytetracycline
include injection site swelling, restlessness, ataxia, trembling,
eyelids, ears, muzzle, anus and vulva (or scrotum and sheath in males),
respiratory abnormalities (labored breathing), frothing at the mouth,
and possibly death. Some of these reactions may be attributed to
allergic reaction) or to cardiovascular collapse of unknown cause.
Store at room temperature 15°-30°C (59°-86°F). Keep from freezing.
CARE OF SICK
ANIMALS: The use of antibiotics
in the management of diseases is based on an accurate diagnosis and an
course of treatment. When properly used in the treatment of diseases
oxytetracycline-susceptible organisms, most animals that have been
Liquamycin LA-200 show a noticeable improvement within 24-48 hours. It
recommended that the diagnosis and treatment of animal diseases be
by a veterinarian. Since many diseases look alike but require different
treatment, the use of professional veterinary and laboratory services
treatment time, costs, and needless losses. Good housing, sanitation,
nutrition are important in the maintenance of healthy animals, and are
in the treatment of diseased animals.
Liquamycin LA-200 is intended for use
in the treatment of the following diseases in beef cattle; dairy cattle;
including preruminating (veal) calves; and swine when due to
Liquamycin LA-200 is indicated in the treatment of pneumonia and
complex associated with Pasteurella spp. and Hemophilus
infectious bovine keratoconjunctivitis (pinkeye) caused by Moraxella
foot rot and diphtheria caused by Fusobacterium necrophorum;
enteritis (scours) caused by Escherichia coli; wooden tongue
Actinobacillus lignieresii; leptospirosis caused by Leptospira
and wound infections and acute metritis caused by strains of
streptococci organisms sensitive to oxytetracycline.
Liquamycin LA-200 is indicated in the treatment of bacterial enteritis
colibacillosis) caused by Escherichia coli; pneumonia caused by
Pasteurella multocida; and leptospirosis caused by Leptospira
In sows, Liquamycin
LA-200 is indicated as an aid in the control of infectious enteritis
scours, colibacillosis) in suckling pigs caused by Escherichia coli.
Liquamycin LA-200 is to be administered by subcutaneous (SC, under the
intravenous injection according to Beef Quality Assurance Guidelines.
A single dosage of 9
mg of Liquamycin LA-200 per lb of body weight administered
recommended in the treatment of the following conditions: 1) bacterial
caused by Pasteurella spp. (shipping fever) in calves and
where retreatment is impractical due to husbandry conditions, such as
range, or where their repeated restraint is inadvisable; 2) infectious
keratoconjunctivitis (pinkeye) caused by Moraxella bovis.
Liquamycin LA-200 can
also be administered by subcutaneous or intravenous injection at a level
mg of oxytetracycline per lb of body weight per day. In the treatment of
foot rot and advanced cases of other indicated diseases, a dosage level
mg/lb of body weight per day is recommended. Treatment should be
hours following remission of disease signs; however, not to exceed a
total of 4
consecutive days. Consult your veterinarian if improvement is not noted
24-48 hours of the beginning of treatment.
A single dose of 9 mg of Liquamycin LA-200 per lb of body weight
intramuscularly in the neck region is recommended in the treatment
bacterial pneumonia caused by Pasteurella multocida in swine,
retreatment is impractical due to husbandry conditions or where repeated
restraint is inadvisable.
Liquamycin LA-200 can
also be administered by intramuscular injection at a level of 3-5 mg of
oxytetracycline per lb of body weight per day. Treatment should be
24-48 hours following remission of disease signs; however, not to exceed
of 4 consecutive days. Consult your veterinarian if improvement is not
within 24-48 hours of the beginning of treatment.
For sows, administer
once intramuscularly in the neck region 3 mg of oxytetracycline per lb
weight approximately 8 hours before farrowing or immediately after
For swine weighing
25 lb of body weight and under,
Liquamycin LA-200 should be administered undiluted for treatment
mg/lb but should be administered diluted for treatment at 3 or 5
9 mg/lb Dosage
Volume of Undiluted
3 or 5 mg/lb Dosage
Volume of Diluted
*To prepare dilutions,
add 1 one part Liquamycin LA-200 to 3, 5, or 7 parts of sterile water,
dextrose solution as indicated; the diluted product should be used
DIRECTIONS FOR USE:
Liquamycin LA-200 is intended for use in the treatment of disease due to
oxytetracycline-susceptible organisms in beef cattle; dairy cattle;
including preruminating (veal) calves; and swine. A thoroughly cleaned,
needle and syringe should be used for each injection (needles and
be sterilized by boiling in water for 15 minutes). In cold weather,
LA-200 should be warmed to room temperature before administration to
Before withdrawing the solution from the bottle, disinfect the rubber
cap on the
bottle with suitable disinfectant, such as 70% alcohol. The injection
should be similarly cleaned with the disinfectant. Needles of 16-18
1-1˝ inches long are adequate for intramuscular and subcutaneous
Needles 2-3 inches are recommended for intravenous use.
injections in swine should be made by directing the needle of suitable
length into the fleshy part of a thick muscle in the neck region; avoid
vessels and major nerves. Before injecting the solution, pull back
gently on the
plunger. If blood appears in the syringe, a blood vessel has been
withdraw the needle and select a different site. No more than 5 mL
injected at any one site in adult swine; rotate injection sites for each
injections in beef cattle, dairy cattle, and calves, including
(veal) calves, should be made by directing the needle of suitable gauge
length through the loose folds of the neck skin in front of the
should be taken to ensure that the tip of the needle has penetrated the
is not lodged in muscle. Before injecting the solution, pull back gently
plunger. If blood appears in the syringe, a blood vessel has been
withdraw the needle and select a different site. The solution should be
slowly into the area between the skin and muscles. No more than 10 mL
injected subcutaneously at any one site in adult beef cattle and dairy
rotate injection sites for each succeeding treatment. The volume
per injection site should be reduced according to age and body size so
mL per site is injected in small calves.
Liquamycin LA-200 may
be administered intravenously to beef and dairy cattle. As with all
concentrated materials, Liquamycin LA-200 should be administered slowly
Preparation of the
Animal for Injection:
location of vein. The jugular vein runs in the jugular groove on each
the neck from the angle of the jaw to just above the brisket and
and to the side of the windpipe (see Fig. I).
2. Restraint. A
stanchion or chute is ideal for restraining the animal. With a halter,
cattle leader (nose tongs), pull the animal's head around the side of
stanchion, cattle chute, or post in such a manner to form a bow in the
Fig. II), then snub the head securely to prevent movement. By forming
the bow in
the neck, the outside curvature of the bow tends to expose the jugular
make it easily accessible. Caution: Avoid restraining the animal
tight rope or halter around the throat or upper neck which might impede
flow. Animals that are down present no problem so far as restraint is
3. Clip hair in area
where injection is to be made (over the vein in the upper third of the
Clean and disinfect the skin with alcohol or other suitable antiseptic.
Entering the Vein
and Making the Injection:
1. Raise the vein.
This is accomplished by tying the choke rope tightly around the neck
the shoulder. The rope should be tied in such a way that it will not
and so that it can be untied quickly by pulling the loose end (see Fig.
thick-necked animals, a block of wood placed in the jugular groove
rope and the hide will help considerably in applying the desired
pressure at the
right point. The vein is a soft flexible tube through which blood flows
the heart. Under ordinary conditions it cannot be seen or felt with the
When the flow of blood is blocked at the base of the neck by the choke
vein becomes enlarged and rigid because of the back pressure. If the
is sufficiently tight, the vein stands out and can be easily seen and
thin-necked animals. As a further check in identifying the vein, tap it
fingers in front of the choke rope. Pulsations that can be seen or felt
fingers in front of the point being tapped will confirm the fact that
is properly distended. It is impossible to put the needle into the vein
it is distended. Experienced operators are able to raise the vein simply
pressure, but the use of a choke rope is more certain.
2. Inserting the
needle. This involves 3 distinct steps. First, insert the needle through
hide. Second, insert the needle into the vein. This may require 2 or 3
before the vein is entered. The vein has a tendency to roll away from
of the needle, especially if the needle is not sharp. The vein can be
with the thumb and finger of one hand. With the other hand, the needle
placed directly over the vein, slanting it so that its direction is
length of the vein, either toward the head or toward the heart. Properly
positioned this way, a quick thrust of the needle will be followed by a
blood through the needle, which indicates that the vein has been
once in the vein, the needle should be inserted along the length of the
the way to the hub, exercising caution to see that the needle does not
the opposite side of the vein. Continuous steady flow of blood through
needle indicates that the needle is still in the vein. If blood does not
continuously, the needle is out of the vein (or clogged) and another
must be made. If difficulty is encountered, it may be advisable to use
on the other side of the neck.
3. While the needle is
being placed in proper position in the vein, an assistant should get the
medication ready so that the injection can be started without delay
vein has been entered.
4. Making the
injection. With the needle in position as indicated by continuous flow
release the choke rope by a quick pull on the free end. This is
essential - the
medication cannot flow into the vein while it is blocked. Immediately
the syringe containing Liquamycin LA-200 to the needle and slowly
plunger. If there is resistance to depression of the plunger, this
that the needle has slipped out of the vein (or is clogged) and the
will have to be repeated. Watch for any swelling under the skin near the
which would indicate that the medication is not going into the vein.
occur, it is best to try the vein on the opposite side of the neck.
5. Removing the
needle. When injection is complete, remove needle with straight pull.
pressure over the area of injection momentarily to control any bleeding
needle puncture, using cotton soaked in alcohol or other suitable
(California) - Use Only As Directed
WARNING: Not For