Pfizer
Antibiotic
Each mL contains
200 mg of oxytetracycline base as oxytetracycline dihydrate.
For use in beef
cattle; dairy cattle; calves, including preruminating (veal) calves; and
swine
For animal use only
Read Entire Package
Insert Carefully Before Using This Product
Liquamycin LA-200 (oxytetracycline
injection) is a sterile, ready-to-use solution for the administration of
the
broad-spectrum antibiotic oxytetracycline (Terramycin®) by
injection.
Terramycin, discovered by Pfizer scientists, is an antimicrobial agent
that is
effective in the treatment of a wide range of diseases caused by
susceptible
gram-positive and gram-negative bacteria.
Liquamycin LA-200
administered to cattle or swine for the treatment of bacterial pneumonia
at a
dosage of 9 mg of oxytetracycline per lb of body weight has been
demonstrated in
clinical trials to be as effective as 2 or 3 repeated, daily treatments
of
Terramycin® Injectable at 3-5 mg/lb of body weight.
Liquamycin LA-200 does
not require refrigeration; however, it is recommended that it be stored
at room
temperature, 15°-30°C (59°-86°F). The antibiotic activity of
oxytetracycline is
not appreciably diminished in the presence of body fluids, serum, or
exudates.
CAUTION:
When administered to cattle, muscle
discoloration may necessitate trimming of the injection site(s) and
surrounding
tissues during the dressing procedure.
WARNING
Discontinue
treatment at least 28 days prior to slaughter of cattle and swine.
Milk
taken from animals during treatment and for 96 hours after the last
treatment must not be used for food. Rapid intravenous
administration may
result in animal collapse. Oxytetracycline should be administered
intravenously slowly over a period of at least 5 minutes. |
PRECAUTIONS:
Exceeding the highest recommended level
of drug per lb of body weight per day, administering more than the
recommended
number of treatments, and/or exceeding 10 mL subcutaneously per
injection site
in adult beef cattle and dairy cattle, and 5 mL intramuscularly per
injection
site in adult swine, may result in antibiotic residues beyond the
withdrawal
period.
Consult with your
veterinarian prior to administering this product in order to determine
the
proper treatment required in the event of an adverse reaction. At the
first sign
of any adverse reaction, discontinue use of the product and seek the
advice of
your veterinarian. Some of the reactions may be attributed either to
anaphylaxis
(an allergic reaction) or to cardiovascular collapse of unknown cause.
Shortly after
injection, treated animals may have transient hemoglobinuria resulting
in
darkened urine.
As with all antibiotic
preparations, use of this drug may result in overgrowth of
nonsusceptible
organisms, including fungi. A lack of response by the treated animal, or
the
development of new signs, may suggest that an overgrowth of
nonsusceptible
organisms has occurred. If any of these conditions occur, consult your
veterinarian.
Since bacteriostatic
drugs may interfere with the bactericidal action of penicillin, it is
advisable
to avoid giving Liquamycin LA-200 in conjunction with penicillin.
ADVERSE REACTIONS:
Reports of adverse reactions associated with oxytetracycline
administration
include injection site swelling, restlessness, ataxia, trembling,
swelling of
eyelids, ears, muzzle, anus and vulva (or scrotum and sheath in males),
respiratory abnormalities (labored breathing), frothing at the mouth,
collapse
and possibly death. Some of these reactions may be attributed to
anaphylaxis (an
allergic reaction) or to cardiovascular collapse of unknown cause.
STORAGE:
Store at room temperature 15°-30°C (59°-86°F). Keep from freezing.
CARE OF SICK
ANIMALS: The use of antibiotics
in the management of diseases is based on an accurate diagnosis and an
adequate
course of treatment. When properly used in the treatment of diseases
caused by
oxytetracycline-susceptible organisms, most animals that have been
treated with
Liquamycin LA-200 show a noticeable improvement within 24-48 hours. It
is
recommended that the diagnosis and treatment of animal diseases be
carried out
by a veterinarian. Since many diseases look alike but require different
types of
treatment, the use of professional veterinary and laboratory services
can reduce
treatment time, costs, and needless losses. Good housing, sanitation,
and
nutrition are important in the maintenance of healthy animals, and are
essential
in the treatment of diseased animals.
INDICATIONS:
Liquamycin LA-200 is intended for use
in the treatment of the following diseases in beef cattle; dairy cattle;
calves,
including preruminating (veal) calves; and swine when due to
oxytetracycline-susceptible
organisms:
Cattle:
Liquamycin LA-200 is indicated in the treatment of pneumonia and
shipping fever
complex associated with Pasteurella spp. and Hemophilus
spp.;
infectious bovine keratoconjunctivitis (pinkeye) caused by Moraxella
bovis;
foot rot and diphtheria caused by Fusobacterium necrophorum;
bacterial
enteritis (scours) caused by Escherichia coli; wooden tongue
caused by
Actinobacillus lignieresii; leptospirosis caused by Leptospira
pomona;
and wound infections and acute metritis caused by strains of
staphylococci and
streptococci organisms sensitive to oxytetracycline.
Swine:
Liquamycin LA-200 is indicated in the treatment of bacterial enteritis
(scours,
colibacillosis) caused by Escherichia coli; pneumonia caused by
Pasteurella multocida; and leptospirosis caused by Leptospira
pomona.
In sows, Liquamycin
LA-200 is indicated as an aid in the control of infectious enteritis
(baby pig
scours, colibacillosis) in suckling pigs caused by Escherichia coli.
DOSAGE:
Cattle:
Liquamycin LA-200 is to be administered by subcutaneous (SC, under the
skin), or
intravenous injection according to Beef Quality Assurance Guidelines.
A single dosage of 9
mg of Liquamycin LA-200 per lb of body weight administered
subcutaneously is
recommended in the treatment of the following conditions: 1) bacterial
pneumonia
caused by Pasteurella spp. (shipping fever) in calves and
yearlings,
where retreatment is impractical due to husbandry conditions, such as
cattle on
range, or where their repeated restraint is inadvisable; 2) infectious
bovine
keratoconjunctivitis (pinkeye) caused by Moraxella bovis.
Liquamycin LA-200 can
also be administered by subcutaneous or intravenous injection at a level
of 3-5
mg of oxytetracycline per lb of body weight per day. In the treatment of
severe
foot rot and advanced cases of other indicated diseases, a dosage level
of 5
mg/lb of body weight per day is recommended. Treatment should be
continued 24-48
hours following remission of disease signs; however, not to exceed a
total of 4
consecutive days. Consult your veterinarian if improvement is not noted
within
24-48 hours of the beginning of treatment.
Swine:
A single dose of 9 mg of Liquamycin LA-200 per lb of body weight
administered
intramuscularly in the neck region is recommended in the treatment
of
bacterial pneumonia caused by Pasteurella multocida in swine,
where
retreatment is impractical due to husbandry conditions or where repeated
restraint is inadvisable.
Liquamycin LA-200 can
also be administered by intramuscular injection at a level of 3-5 mg of
oxytetracycline per lb of body weight per day. Treatment should be
continued
24-48 hours following remission of disease signs; however, not to exceed
a total
of 4 consecutive days. Consult your veterinarian if improvement is not
noted
within 24-48 hours of the beginning of treatment.
For sows, administer
once intramuscularly in the neck region 3 mg of oxytetracycline per lb
of body
weight approximately 8 hours before farrowing or immediately after
completion of
farrowing.
For swine weighing
25 lb of body weight and under,
Liquamycin LA-200 should be administered undiluted for treatment
at 9
mg/lb but should be administered diluted for treatment at 3 or 5
mg/lb.
Body
Weight |
9 mg/lb Dosage
Volume of Undiluted
Liquamycin LA-200 |
3 or 5 mg/lb Dosage
Volume of Diluted
Liquamycin LA-200 |
9 mg/lb |
3 mg/lb |
Dilution* |
5 mg/lb |
5 lb |
0.2 mL |
0.6 mL |
1:7 |
1.0 mL |
10 lb |
0.5 mL |
0.9 mL |
1:5 |
1.5 mL |
25 lb |
1.1 mL |
1.5 mL |
1:3 |
2.5 mL |
*To prepare dilutions,
add 1 one part Liquamycin LA-200 to 3, 5, or 7 parts of sterile water,
or 5%
dextrose solution as indicated; the diluted product should be used
immediately.
DIRECTIONS FOR USE:
Liquamycin LA-200 is intended for use in the treatment of disease due to
oxytetracycline-susceptible organisms in beef cattle; dairy cattle;
calves,
including preruminating (veal) calves; and swine. A thoroughly cleaned,
sterile
needle and syringe should be used for each injection (needles and
syringes may
be sterilized by boiling in water for 15 minutes). In cold weather,
Liquamycin
LA-200 should be warmed to room temperature before administration to
animals.
Before withdrawing the solution from the bottle, disinfect the rubber
cap on the
bottle with suitable disinfectant, such as 70% alcohol. The injection
site
should be similarly cleaned with the disinfectant. Needles of 16-18
gauge and
1-1˝ inches long are adequate for intramuscular and subcutaneous
injections.
Needles 2-3 inches are recommended for intravenous use.
Intramuscular
Administration:
Intramuscular
injections in swine should be made by directing the needle of suitable
gauge and
length into the fleshy part of a thick muscle in the neck region; avoid
blood
vessels and major nerves. Before injecting the solution, pull back
gently on the
plunger. If blood appears in the syringe, a blood vessel has been
entered;
withdraw the needle and select a different site. No more than 5 mL
should be
injected at any one site in adult swine; rotate injection sites for each
succeeding treatment.
Subcutaneous
Administration:
Subcutaneous
injections in beef cattle, dairy cattle, and calves, including
preruminating
(veal) calves, should be made by directing the needle of suitable gauge
and
length through the loose folds of the neck skin in front of the
shoulder. Care
should be taken to ensure that the tip of the needle has penetrated the
skin but
is not lodged in muscle. Before injecting the solution, pull back gently
on the
plunger. If blood appears in the syringe, a blood vessel has been
entered;
withdraw the needle and select a different site. The solution should be
injected
slowly into the area between the skin and muscles. No more than 10 mL
should be
injected subcutaneously at any one site in adult beef cattle and dairy
cattle;
rotate injection sites for each succeeding treatment. The volume
administered
per injection site should be reduced according to age and body size so
that 1-2
mL per site is injected in small calves.
Intravenous
Administration:
Liquamycin LA-200 may
be administered intravenously to beef and dairy cattle. As with all
highly
concentrated materials, Liquamycin LA-200 should be administered slowly
by the
intravenous route.
Preparation of the
Animal for Injection:
1. Approximate
location of vein. The jugular vein runs in the jugular groove on each
side of
the neck from the angle of the jaw to just above the brisket and
slightly above
and to the side of the windpipe (see Fig. I).
2. Restraint. A
stanchion or chute is ideal for restraining the animal. With a halter,
rope, or
cattle leader (nose tongs), pull the animal's head around the side of
the
stanchion, cattle chute, or post in such a manner to form a bow in the
neck (see
Fig. II), then snub the head securely to prevent movement. By forming
the bow in
the neck, the outside curvature of the bow tends to expose the jugular
vein and
make it easily accessible. Caution: Avoid restraining the animal
with a
tight rope or halter around the throat or upper neck which might impede
blood
flow. Animals that are down present no problem so far as restraint is
concerned.
3. Clip hair in area
where injection is to be made (over the vein in the upper third of the
neck).
Clean and disinfect the skin with alcohol or other suitable antiseptic.

Entering the Vein
and Making the Injection:
1. Raise the vein.
This is accomplished by tying the choke rope tightly around the neck
close to
the shoulder. The rope should be tied in such a way that it will not
come loose
and so that it can be untied quickly by pulling the loose end (see Fig.
II). In
thick-necked animals, a block of wood placed in the jugular groove
between the
rope and the hide will help considerably in applying the desired
pressure at the
right point. The vein is a soft flexible tube through which blood flows
back to
the heart. Under ordinary conditions it cannot be seen or felt with the
fingers.
When the flow of blood is blocked at the base of the neck by the choke
rope, the
vein becomes enlarged and rigid because of the back pressure. If the
choke rope
is sufficiently tight, the vein stands out and can be easily seen and
felt in
thin-necked animals. As a further check in identifying the vein, tap it
with the
fingers in front of the choke rope. Pulsations that can be seen or felt
with the
fingers in front of the point being tapped will confirm the fact that
the vein
is properly distended. It is impossible to put the needle into the vein
unless
it is distended. Experienced operators are able to raise the vein simply
by hand
pressure, but the use of a choke rope is more certain.
2. Inserting the
needle. This involves 3 distinct steps. First, insert the needle through
the
hide. Second, insert the needle into the vein. This may require 2 or 3
attempts
before the vein is entered. The vein has a tendency to roll away from
the point
of the needle, especially if the needle is not sharp. The vein can be
steadied
with the thumb and finger of one hand. With the other hand, the needle
point is
placed directly over the vein, slanting it so that its direction is
along the
length of the vein, either toward the head or toward the heart. Properly
positioned this way, a quick thrust of the needle will be followed by a
spurt of
blood through the needle, which indicates that the vein has been
entered. Third,
once in the vein, the needle should be inserted along the length of the
vein all
the way to the hub, exercising caution to see that the needle does not
penetrate
the opposite side of the vein. Continuous steady flow of blood through
the
needle indicates that the needle is still in the vein. If blood does not
flow
continuously, the needle is out of the vein (or clogged) and another
attempt
must be made. If difficulty is encountered, it may be advisable to use
the vein
on the other side of the neck.
3. While the needle is
being placed in proper position in the vein, an assistant should get the
medication ready so that the injection can be started without delay
after the
vein has been entered.
4. Making the
injection. With the needle in position as indicated by continuous flow
of blood,
release the choke rope by a quick pull on the free end. This is
essential - the
medication cannot flow into the vein while it is blocked. Immediately
connect
the syringe containing Liquamycin LA-200 to the needle and slowly
depress the
plunger. If there is resistance to depression of the plunger, this
indicates
that the needle has slipped out of the vein (or is clogged) and the
procedure
will have to be repeated. Watch for any swelling under the skin near the
needle,
which would indicate that the medication is not going into the vein.
Should this
occur, it is best to try the vein on the opposite side of the neck.
5. Removing the
needle. When injection is complete, remove needle with straight pull.
Then apply
pressure over the area of injection momentarily to control any bleeding
through
needle puncture, using cotton soaked in alcohol or other suitable
antiseptic.
Restricted Drug
(California) - Use Only As Directed
WARNING: Not For
Human Use
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