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What Glucosamine Does As a natural dog food supplement, glucosamine can soothe the symptoms of arthritis in dogs. Glucosamine supplements work to restore and regenerate your dog's damaged joints. They also have anti-inflammatory properties. Glucosamine for dogs can be used as a preventative measure in elderly dogs who are at high risk for arthritis. Glucosamine supplements for dogs can help treat the symptoms of dogs already suffering from arthritis. Within two weeks to thirty days, you should notice that your dog has become more lively and active. Some owners report a full recovery from symptoms of arthritis.