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Modified Live Virus
For the vaccination of healthy cattle as an aid in the prevention of disease caused by bovine rhinotracheitis virus, L. hardjo, and L. pomona. This vaccine may be used in pregnant cows or calves nursing pregnant cows provided the cows were vaccinated pre-breeding, according to label instructions, with Pyramid 5, Pyramid 10, or Pyramid 2 + Type II BVD (see inside carton for details).
Safety in pregnant cows and heifers was demonstrated in trials conducted in three separate herds of more than 1,400 cows. Prior to breeding, all animals were vaccinated with Pyramid® 5, a modified-live virus (MLV) vaccine containing IBR, BVD Type I & II, PI3 and BRSV. During the first, second or third trimester of pregnancy, the animals were vaccinated again. The pregnant cows received either Pyramid 5 or a killed virus (KV) IBR, BVD Type I & II, PI3 and BRSV vaccine (Triangle® 4 + Type II BVD). From pregnancy vaccination through calving, the cows were observed for fetal loss. Fetal loss in both groups was similar with 0.9% in the Pyramid 5 vaccinated groups and 1.6% in the KV vaccinated groups. In addition, no abortions due to IBR or BVD were identified in either group. Following birth, each calf's health was monitored for 30 days. The health of calves born to Pyramid 5 vaccinated dams was similar to the health of calves born to the KV vaccinated dams. Fetal health risks associated with vaccination of pregnant animals with modified-live vaccines cannot be unequivocally determined by clinical trials conducted for Iicensure. Vaccination of pregnant animals with modified-live vaccines should be discussed with a veterinarian.
For Veterinary Use Only
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U.S. Vet. License No. 112