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RespiSure-One
RespiSure-One
RespiSure-One


 
RESPISURE 1 ONE® is for vaccination of healthy swine 1 week of age or older as an aid in preventing chronic pneumonia caused by Mycoplasma hyopneumoniae for a period of 25 weeks following vaccination.

Item# Item Name Our Price Qty Add
877-024036 RespiSure-One 250 dose 500ml
$142.79
877-024035 RespiSure-One 50 dose 100ml
$31.38
877-024037 RespiSure-One 500 dose 1000ml
$277.98
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Extended Information:

RESPISURE 1 ONE®

Pfizer Animal Health

Mycoplasma Hyopneumoniae Bacterin

U.S. Vet. Lic. No.: 189

Description: RESPISURE 1 ONE® is a liquid preparation of a chemically inactivated whole cell culture of M. hyopneumoniae, coupled with a unique oil adjuvant Amphigen® to enhance and prolong the immune response without causing detectable tissue damage at the injection site.

Indications: RESPISURE 1 ONE® is for vaccination of healthy swine 1 week of age or older as an aid in preventing chronic pneumonia caused by Mycoplasma hyopneumoniae for a period of 25 weeks following vaccination.

Directions:

1. General Directions: Shake well. Aseptically administer 2 mL intramuscularly.

2. Primary Vaccination: Administer a single 2 mL dose to healthy swine 1 week of age or older.

3. Revaccination: Semiannual revaccination with a single dose is recommended.

4. Good animal husbandry and herd health management practices should be employed.

Precaution(s): Store at 2°-7°C. Prolonged exposure to higher temperatures may adversely affect potency. Do not freeze.

Use entire contents when first opened.

Sterilized syringes and needles should be used to administer this vaccine.

Caution(s): As with many vaccines, anaphylaxis may occur after use. Initial antidote of epinephrine is recommended and should be followed with appropriate supportive therapy.

This product has been shown to be efficacious in healthy animals. A protective immune response may not be elicited if animals are incubating an infectious disease, are malnourished or parasitized, are stressed due to shipment or environmental conditions, are otherwise immunocompromised, or the vaccine is not administered in accordance with label directions.

For use in swine only

For veterinary use only

Warning(s): Do not vaccinate within 21 days before slaughter.

Discussion: Disease Description: Mycoplasmal pneumonia of swine (MPS) or enzootic pneumonia is a widespread, chronic disease characterized by coughing, growth retardation, and reduced feed efficiency. The etiologic agent is M. hyopneumoniae; however, the naturally occurring disease often results from a combination of bacterial and mycoplasmal infections.

MPS causes considerable economic loss in all areas where swine are raised. Surveys conducted at various locations throughout the world indicate that lesions typical of those seen with MPS occur in 30%-80% of slaughter-weight swine. Because mycoplasmal lesions may resolve before hogs reach slaughter weight, the actual incidence may be higher. The prevalence of M. hyopneumoniae infection in chronic swine pneumonia has been reported to range from 25%1-93%.2 Pigs of all ages are susceptible to MPS, but the disease is most common in growing and finishing swine. Current evidence indicates that M. hyopneumoniae is transmitted by aerosol or direct contact with respiratory tract secretions from infected swine. Transmission from sow to pig during lactation is possible.3 Once established, MPS occurs year after year in infected herds, varying in severity with such environmental factors as season, ventilation, and concentration of swine.

Clinical signs of MPS include a chronic, nonproductive cough continuing for weeks or months, unthrifty appearance, and retarded growth, even though the appetites of infected swine remain normal. Stunting may occur, resulting in considerable variation in size among affected pigs. Death loss associated with secondary bacterial infection and stress may occur.

M. hyopneumoniae causes a loss of ciliary motility in the bronchial passages. Eventually the cilia are destroyed, resulting in reduction in natural defense in the upper respiratory tract and increased susceptibility to secondary infection with bacterial agents such as Pasteurella multocida, Haemophilus parasuis, Actinobacillus pleuropneumoniae, and Bordetella bronchiseptica. Swine lungworm and roundworm larvae infections may also increase the severity of MPS.

Trial Data: Safety and Efficacy: In clinical studies conducted by Pfizer Animal Health, RESPISURE 1 ONE® has been shown to be safe and free from significant adverse reactions when administered according to label directions. Chemical inactivation renders RESPISURE 1 ONE® incapable of causing infectious disease. The oil-base adjuvant in RESPISURE 1 ONE® does not produce the major tissue damage sometimes associated with conventional oil adjuvants.

Efficacy of RESPISURE 1 ONE® was demonstrated in host animal studies conducted by Pfizer; duration-of-immunity studies demonstrated efficacy up to 25 weeks after a single vaccination in pigs as young as 1 week of age. In all of these duration-of-immunity studies, pigs vaccinated with RESPISURE 1 ONE®, followed by challenge, had significantly lower lung lesion scores than pigs vaccinated with a placebo.

Duration-of-immunity studies: The purpose of the 7 studies below in Table 1 was to demonstrate protection against challenge with virulent M. hyopneumoniae 8, 18, 23 or 25 weeks after a single vaccination with RESPISURE 1 ONE® in 1-, 3- or 8-week-old pigs. All pigs were necropsied and lung lesion scores determined (percent of total lung with lesions4). In all cases pigs vaccinated with RESPISURE 1 ONE® had significantly lower lung lesion scores than pigs vaccinated with a placebo.

Table 1.

Study

Treatment

No. of Pigs

Vaccination (age in wks)

Challenge (wks after vacc)

Challenge (age in wks)

% Lung Lesion

1

Placebo

22

3

8

11

2.7a

RESPISURE 1 ONE®

24

3

8

11

0.1b

2

Placebo

20

3

18

21

13.2a

RESPISURE 1 ONE®

19

3

18

21

5.5b

3

Placebo

18

8

8

16

10.3a

RESPISURE 1 ONE®

20

8

8

16

0.5b

4

Placebo

21

8

18

26

9.6a

RESPISURE 1 ONE®

20

8

18

26

0.9b

5

Placebo

19

3

23

26

9.0a

RESPISURE 1 ONE®

22

3

23

26

2.1b

6

Placebo

26*

1

25

26

4.5a

RESPISURE 1 ONE®

22*

1

25

26

2.0b

7

Placebo

24

1

25

26

5.9a

RESPISURE 1 ONE®

20

1

25

26

0.3b

a,b Within each study group, values with different superscripts are statistically significant vs. placebo (p≤0.05).

* Pigs were serologically positive for M. hyopneumoniae.

References: Available upon request.

75-5001-05

Presentation: 15 dose (30 mL), 250 dose (500 mL), and 500 dose (1,000 mL) bottles.

NAC No.: 36900341




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