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Thyro-Tabs (RX)
Thyro-Tabs (RX)
Thyro-Tabs (RX)


 
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For use in the correction of conditions associated with hypothyroidism in dogs. Small scored caplets. Active ingredient: levothyroxine sodium.

Item# Item Name Our Price Qty Add
71-007889 Thyro-Tabs (RX) 0.1mg. 1000 ct.
$34.99
71-004036 Thyro-Tabs (RX) 0.1mg. 120 ct.
$8.95
71-007890 Thyro-Tabs (RX) 0.2mg. 1000 ct.
$51.79
71-004037 Thyro-Tabs (RX) 0.2mg. 120 ct.
$9.95
71-007891 Thyro-Tabs (RX) 0.3mg. 1000 ct.
$68.73
71-004038 Thyro-Tabs (RX) 0.3mg. 120 ct.
$9.95
71-007377 Thyro-Tabs (RX) 0.4mg. 1000 ct.
$86.35
71-000262 Thyro-Tabs (RX) 0.4mg. 120 ct.
$12.95
71-007892 Thyro-Tabs (RX) 0.5mg. 1000 ct.
$104.08
71-004040 Thyro-Tabs (RX) 0.5mg. 120 ct.
$15.49
71-002856 Thyro-Tabs (RX) 0.6mg. 1000 ct.
$115.99
71-005364 Thyro-Tabs (RX) 0.6mg. 120 ct.
$17.29
71-011062 Thyro-Tabs (RX) 0.7mg. 1000 ct.
$129.95
71-012582 Thyro-Tabs (RX) 0.7mg. 120 ct.
$19.29
71-007893 Thyro-Tabs (RX) 0.8mg. 1000 ct.
$139.29
71-004042 Thyro-Tabs (RX) 0.8mg. 120 ct.
$20.49
71-025784 Thyro-Tabs (RX) 1.0mg. 1000 ct.
$149.99
71-025783 Thyro-Tabs (RX) 1.0mg. 120 ct.
$21.59
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Features:
For use in dogs for correction of conditions associated with low circulating thyroid hormone (hypothyroidism).



Extended Information:

THYRO-TABS

Vet-A-Mix

(Levothyroxine sodium tablets, USP)

Caplets

Caution: Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Description: Each Thyro-Tabs Caplet contains synthetic crystalline levothyroxine sodium, USP.

The structural formula for levothyroxine sodium is:

Indications: For use in dogs for correction of conditions associated with low circulating thyroid hormone (hypothyroidism).

Low serum circulating L-thyroxine (T-4) concentrations, coupled with clinical signs, are suggestive of hypothyroidism. Based on studies conducted by Vet-A-Mix and in cooperation with two commercial laboratories, the following parameters for T-4 concentrations in canine serum have been established:

Normal (euthyroid) - 18 to 32 ng/mL (1.8 to 3.2 g/dL)

Possible hypothyroid - 10 to 18 ng/mL (1.0 to 1.8 g/dL)

Hypothyroid - less than 10 ng/mL (< 1.0 g/dL) The animal should be showing some clinical signs associated with hypothyroidism.

A resting serum T-4 concentration of 18 ng/mL or above signifies that hypothyroidism is unlikely in dogs. Normally, the greater the T-4 concentration exceeds this value, the less likely that a dog is hypothyroid. A dog with a T-4 value below 18 ng/mL that is exhibiting signs of hypothyroidism should be considered for levothyroxine replacement therapy.

T-4 measurements should be made at 30 day intervals to establish the proper maintenance dose during a therapeutic trial with Thyro-Tabs Caplet. A critical assessment of improvement in or resolution of clinical signs should be made after 12 weeks of levothyroxine sodium therapy. Further confirmation of the diagnosis could include withdrawal of the levothyroxine sodium therapy. A recurrence of clinical signs following cessation of therapy further supports the diagnosis. Correct diagnosis of hypothyroidism is important, since such a diagnosis normally commits an animal to life-long supplemental L-thyroxine replacement therapy. The principal objective of levothyroxine sodium administration is to achieve and maintain normal metabolism in the patient by providing an exogenous supply of synthetic L-thyroxine in amounts sufficient to maintain levels of the hormone within the animal's normal physiologic range. Animal adaptation may necessitate regular monitoring of serum T-4 concentrations during the first several months of treatment to establish proper maintenance doses.

The TSH Response Test may be used to provide a definitive diagnosis in dogs with borderline resting serum T-4 values. The TSH dose, post-dose sampling times, and interpretation of pre- and post-TSH injection responses depend somewhat on the reference laboratory used.

Mode of actions: Levothyroxine sodium provided by Thyro-Tabs Caplet cannot be distinguished from L-thyroxine endogenously secreted by the thyroid gland. L-thyroxine is a naturally circulating thyroid hormone released by the thyroid gland. The primary regulator of thyroid function is thyroid stimulating hormone (TSH) which is synthesized and secreted by the pars distalis of the adenohypophysis (anterior pituitary). The mediator from the hypothalamus which exerts a continuous influence over the pituitary release of TSH is thyrotropin-releasing hormone (TRH). Thyroid hormones influence virtually every body organ, either by their effect on growth and development or by the hormones' metabolic effects.

Occurrence of canine hypothyroidism: Hypothyroidism usually occurs in middle-aged and older dogs although the condition will sometimes be seen in younger dogs of the larger breeds. Neutered animals of either sex are also frequently affected, regardless of age. The condition is usually primary, failure of the thyroid gland, because of lymphocytic thyroiditis or other loss of follicular epithelium and resulting atrophy of the gland. Secondary hypothyroidism is relatively rare and usually due to a destructive pituitary tumor.

Clinical signs of canine hypothyroidism: Not all dogs with hypothyroidism will have classical clinical signs and laboratory findings. The following list of clinical signs and laboratory findings may vary in dogs with hypothyroidism depending upon the degree and length of time of the thyroid dysfunction:

Nerve and muscle function: lethargy, lack of endurance, increased sleeping, reduced alertness and interest, impaired cerebral function and dulled mental attitude, hypotonus, stiff and slow movements, dragging of forelimbs, head tilt, disturbed balance.

Metabolism: decreased oxygen consumption and lower metabolic rate, sensitivity and intolerance to cold, low body temperature, cool skin, preference for warmth, increased body weight, constipation, poor exercise tolerance, slow heart rate, weak pulse, weak apex heart beat, and low voltage on ECG.

Reproduction: reproductive failure, abortion, stillbirth, live birth of weak young, delayed puberty, reduced libido, impaired spermatogenesis, irregular estrus and anestrus, galactorrhea.

Skin and hair: myxedema of face, blepharoptosis, atrophy of epidermis, thickening of dermis, surface and follicular hyperkeratosis, hyperpigmentation, coarse and sparse coat, dry, dull and brittle hair, slow regrowth and retarded turnover of hair, bilateral alopecia.

Laboratory findings: low serum T-4 concentrations, hypercholesterolemia, hypertriglyceridemia, elevated serum creatine kinase, anemia (normochromic, normocytic).

Contraindications: Levothyroxine sodium therapy is contraindicated in thyrotoxicosis, acute myocardial infarction, and uncorrected adrenal insufficiency. Other conditions in which the use of L-thyroxine replacement therapy may be contraindicated or should be instituted with caution include primary hypertension, euthyroidism, and pregnancy.

Warnings: The administration of levothyroxine sodium to dogs to be used for breeding purposes or in pregnant bitches has not been evaluated. There is evidence to suggest that administration to pregnant bitches may in some instances affect the normal development of the thyroid gland in the unborn pups.

Precautions: The clinical effects of levothyroxine sodium therapy are slow in being manifested. Overdosage of any thyroid drug may produce the signs and symptoms of thyrotoxicosis including, but not limited to: polydypsia, polyuria, polyphagia, reduced heat tolerance and hyperactivity or personality change. Thyro-Tabs Caplet 0.1 mg and 0.7 mg caplets contain FD&C Yellow #5 (tartrazine) which has been associated with allergic-type reactions (including bronchial asthma) in susceptible humans. It is unknown whether such a reaction could also occur in other animals.

Adverse Reactions: There are no specific adverse reactions associated with levothyroxine sodium administration at the recommended dosages. Overdosage will result in the signs of thyrotoxicosis listed above under cautions.

Dosages: The initial recommended daily dose is 0.1 to 0.2 mg/10 pounds (4.5 kg) body weight in single or divided doses. Dosage is then adjusted by monitoring the T-4 blood levels of the dog every four weeks until an adequate maintenance dose is established. The usual daily maintenance dose is 0.1 mg/10 lb (4.5 kg). A maximum of 0.8 to 1.0 mg total daily dose will be sufficient in most dogs over 80 pounds in body weight.

Administration: Thyro-Tabs Caplet may be administered orally or placed in the food.

How Supplied: Thyro-Tabs (levothyroxine sodium tablets, USP) is available as scored, color-coded caplets in 9 concentrations: 0.1 mg -yellow; 0.2 mg - pink; 0.3 mg green; 0.4 mg - maroon; 0.5 mg - white; 0.6 mg - purple; 0.7 mg - orange; 0.8 mg - blue; 1.0 mg - tan; in 28-day strip packs and bottles of 120 and 1000.

Storage: Store at controlled room temperature: 15-30C (59-86F) and protect from light.

References:

1. Dickerson, W. M. 1993. Endocrine glands. Pages 629-664 in M. J. Swenson and W. O. Reece, eds. Dukes' Physiology of domestic animals. 11th ed. Cornell University Press, Ithaca, N Y

2. Chastain, C. B. 1992. Unusual manifestations of hypothyroidism in dogs. Pages 330-334 in R. W. Kirk and J. D. Bonagura, eds. Current veterinary therapy XI. W. B. Saunders Company, Philadelphia, PA.

3. Peterson, M. E. 1991. The use of endocrine testing in the diagnosis and treatment of endocrine disorders. Proc. ACVIM Forum 9:109-114.

4. Panciera D. L. 1990. Canine hypothyroidism. Part 1. Clinical findings and control of thyroid hormone secretion and metabolism. The Compendium 12:689-701.

5. McDonald, L. E. 1988. Hormones influencing metabolism. Pages 616-655 in N. H. Booth and L. E. McDonald eds. Veterinary pharmacology and therapeutics. 6th ed. Iowa State University Press, Ames, IA.

6. Nelson, R. W., and S. L. Ihle. 1987. Treating hypothyroidism through hormone supplementation. Vet. Med. 82:153-156.

7. Nelson, R. W., and S. L. Ihle. 1987. Hypothyroidism in dogs and cats: A difficult deficiency to diagnose. Vet. Med. 82:60-70.

8. Chastain, C. B., and V. K. Ganjam. 1986. The thyroid. Pages 110-175 in Clinical endocrinology of companion animals. Lea and Febiger, Philadelphia, PA.

0898

VET A MIX

DESIGNED FOR THE PROFESSION

P.O. Box 130, Shenandoah, IA U.S.A. 51601

712-246-4000

NAC No.: 10500303




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