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FOR INTRAMAMMARY INFUSION
NADA 97-222, Approved by FDA
ToDAY (cephapirin sodium) is a cephalosporin which possesses a wide range of antimicrobial activity against gram-positive and gram-negative organisms. It is derived biosynthetically from 7-aminocephalosporanic acid.
Each 10 mL disposable syringe contains 200 mg of cephapirin activity in a stable peanut oil gel. This product was manufactured by a non-sterilizing process.
Store at controlled room temperature 15° to 30°C (59° to 86°F); avoid excessive heat.
Cephapirin is bactericidal to susceptible organisms; it is known to be highly active against Streptococcus agalactiae and Staphylococcus aureus including strains resistant to penicillin.
To determine the susceptibility of bacteria to cephapirin in the laboratory, the class disc, Cephalothin Susceptibility Test Discs, 30 mcg, should be used.
FOR LACTATING COWS ONLY
For the Treatment of Bovine Mastitis
ToDAY (cephapirin sodium) for Intramammary Infusion should be used at the first signs of inflammation or at the first indication of any alteration in the milk. Treatment is indicated immediately upon determining, by C.M.T. or other tests, that the leucocyte count is elevated, or that a susceptible pathogen has been cultured from the milk.
ToDAY for Intramammary Infusion has been shown to be efficacious in the treatment of mastitis in lactating cows caused by susceptible strains of Streptococcus agalactiae and Staphylococcus aureus including strains resistant to penicillin.
DOSAGE AND DIRECTIONS FOR USE
Infuse the entire contents of one syringe (10 mL) into each infected quarter immediately after the quarter has been completely milked out. Repeat once only in 12 hours. If definite improvement is not noted within 48 hours after treatment, the causal organism should be further investigated. Consult your veterinarian.
Milk out udder completely. Wash the udder and teats thoroughly with warm water containing a suitable dairy antiseptic and dry, preferably using individual paper towels. Carefully scrub the teat end and orifice with 70% alcohol, using a separate swab for each teat. Allow to dry.
ToDAY (cephapirin sodium) is packaged with the Opti-Sert® Protective Cap.
For partial insertion: Twist off upper portion of the Opti-Sert Protective Cap to expose 3-4 mm of the syringe tip.
For full insertion: Remove protective cap to expose the full length of the syringe tip.
Insert syringe tip into the teat canal and expel the entire contents of one syringe into each infected quarter. Withdraw the syringe and gently massage the quarter to distribute the suspension into the milk cistern. Do not milk out for 12 hours.
Do not infuse contents of the mastitis syringe into the teat canal if the Opti-Sert Protective Cap is broken or damaged.
Reinfection - The use of antibiotics, however effective, for the treatment of mastitis will not significantly reduce the incidence of this disease in the herd unless their use is fortified by good herd management, and sanitary and mechanical safety measures are practiced to prevent reinfection.
ToDAY should be administered with caution to subjects which have demonstrated some form of allergy, particularly to penicillin. Such reactions are rare; however, should they occur, discontinue treatment and consult a veterinarian.
1. Milk that has been taken from animals during treatment and for 96 hours after the last treatment must not be used for food.
2. Treated animals must not be slaughtered for food until 4 days after the last treatment.
3. Administration of more than the prescribed dose may lead to residue of antibiotic in milk longer than 96 hours.
ToDAY (cephapirin sodium) for Intramammary Infusion. Cephapirin sodium equivalent to 200 mg of cephapirin activity per syringe.
One 10 mL syringe
Carton containing 12 x 10 mL syringes
NDC 0856-02727-10 - 10 mL - syringe
Opti-Sert® Protective Cap - U.S. Patent No. 4,850, 970
Not for Human Use
Restricted Drug (California) - Use Only as Directed
© 2007 Fort Dodge Animal Health.
All Rights Reserved.
Fort Dodge Animal Health, Fort Dodge, Iowa 50501 USA
by G.C. Hanford Manufacturing Co., Syracuse, NY 13201
Rev. Oct. 2007
NAC No.: 10032233