Federal (U.S.A.) law restricts this drug to use by or on
the order of a licensed veterinarian.
estroPLAN injection causes
functional and morphological regression of the corpus luteum (luteolysis) in cattle. In normal, nonpregnant
cycling animals this effect on the life span of the corpus luteum
usually results in estrus 2 to 5 days after treatment. In animals with
prolonged luteal function (pyometra, mummified fetus, and luteal cysts)
the induced luteolysis usually results in resolution of the condition
and return to cyclicity. Pregnant animals may abort depending on the
stage of gestation.
For intramuscular use to induce luteolysis in beef and
dairy cattle. The luteolytic action of estroPLAN
injection can be utilized to manipulate the estrous cycle to better fit
certain management practices, to terminate pregnancies resulting from
mismatings and to treat certain conditions associated with prolonged
Unobserved or Non-detected Estrus
Cows which are not detected in estrus, although ovarian
cyclicity continues, can be treated with estroPLAN
if a mature corpus luteum is present. Estrus is expected to occur 2 to 5
days following injection, at which time animals may be inseminated.
Treated cattle should be inseminated at the usual time following
detection of estrus. If estrus detection is not desirable or possible,
treated animals may be inseminated twice at about 72 and 96 hours post
Pyometra or Chronic Endometritis
Damage to the reproductive tract at calving or post
partum retention of the placenta often leads to infection and
inflammation of the uterus (endometritis). Under certain circumstances,
this may progress into chronic endometritis with the uterus becoming
distended with purulent matter. This condition, commonly referred to as
pyometra, is characterized by a lack of cyclical estrus behavior and the
presence of a persistent corpus luteum. Induction of luteolysis with estroPLAN usually results in evacuation of the uterus
and a return to normal cyclical activity within 14 days after treatment.
After 14 days post treatment, recovery rate of treated animals will not
be different than that of untreated cattle.
Death of the conceptus during gestation may be followed
by its degeneration and dehydration. Induction of luteolysis with estroPLAN usually results in expulsion of the mummified
fetus from the uterus. (Manual assistance may be necessary to remove
the fetus from the vagina.) Normal cyclical activity usually follows.
A cow may be noncyclic due to the presence of a luteal
cyst (a single, anovulatory follicle with a thickened wall which is
accompanied by no external signs and by no changes in palpable
consistency of the uterus). Treatment with estroPLAN
can restore normal ovarian activity by causing regression of the luteal
Pregnancies from Mismating
Unwanted pregnancies can be safely and efficiently
terminated from 1 week after mating until about five months of
gestation. The induced abortion is normally uncomplicated and the fetus
and placenta are usually expelled about four to five days after the
injection with the reproductive tract returning to normal soon after the
abortion. The ability of estroPLAN to induce
abortion decreases beyond the fifth month of gestation while the risk of
dystocia and its consequences increases. estroPLAN
has not been sufficiently tested under feedlot conditions; therefore
recommendations cannot be made for its use in heifers placed in
The luteolytic action of estroPLAN
can be utilized to schedule estrus and ovulation for an individual
cycling animal or a group of animals. This allows control of the time at
which cycling cows or heifers can be bred. estroPLAN
can be incorporated into a controlled breeding program by the following
1. Single estroPLAN Injection - Only
animals with a mature corpus luteum should be treated to obtain maximum
response to the single injection. However, not all cycling cattle
should be treated since a mature corpus luteum is present for only 11 to
12 days of the 21-day cycle.
Prior to treatment, cattle should be examined
rectally and found to be anatomically normal, be non-pregnant and have a
mature corpus luteum. If these criteria are met, estrus is expected to
occur two to five days following injection, at which time animals may be
inseminated. Treated cattle should be inseminated at the usual time
following detection of estrus. If estrus detection is not desirable or
possible, treated animals may be inseminated either once at about 72
hours or twice at about 72 and 96 hours post injection.
With a single injection program, it may be desirable
to assess the cyclicity status of the herd before estroPLAN
treatment. This can be accomplished by heat detecting and breeding at
the usual time following detection of estrus for a 6-day period, all
prior to injection. If by the sixth day the cyclicity status appears
normal (approximately 25 - 30% detected in estrus), all cattle not
already inseminated should be palpated for normality, non-pregnancy, and
cyclicity, then injected with estroPLAN. Breeding
should then be continued at the usual time following signs of estrus on
the seventh and eighth day. On the ninth and tenth day breeding may
continue at the usual time following detection of estrus or all cattle
not already inseminated may be bred either once on the ninth day (at
about 72 hours post injection) or on both the ninth and tenth day (at
about 72 and 96 hours post injection).
2. Double estroPLAN Injections - Prior
to treatment, cattle should be examined rectally and found to be
anatomically normal, non-pregnant, and cycling (the presence of a mature
corpus luteum is not necessary when the first injection of a double
injection regimen is given). A second injection should be given 11 days
after the first injection. In normal, cycling cattle, estrus is expected
2 to 5 days following the second injection. Treated cattle should be
inseminated at the usual time following detection of estrus. If estrus
detection is not desirable or possible, treated animals may be
inseminated either once at about 72 hours or twice at about 72 and 96
hours following the second estroPLAN injection.
Many animals will come into estrus following the
first injection; these animals can be inseminated at the usual time
following detected estrus. Animals not inseminated should receive a
second injection 11 days after the first injection. Animals receiving
both injections may be inseminated at the usual time following detection
of estrus or may be inseminated either once at about 72 hours or twice
at about 72 and 96 hours post second injection.
Any controlled breeding program recommended should be
completed by either:
- observing animals (especially during the third week
after injection) and inseminating or hand mating any animals returning
- turning in clean-up bull(s) 5 to 7 days after the last
injection of estroPLAN to cover any animals
returning to estrus.
REQUIREMENTS FOR CONTROLLED BREEDING
A variety of programs can be designed to best meet the
needs of individual management systems. A controlled breeding program
should be selected which is appropriate for the existing circumstances
and management practices.
Before a controlled breeding program is planned the
producer’s objectives must be examined and he must be made aware of the
projected results and limitations. The producer and his consulting
veterinarian should review the operation’s breeding history, herd health
and nutritional status and agree that a controlled breeding program is
practical in the producer’s specific situation. For any successful
controlled breeding program:
- cows and heifers must be normal, nonpregnant, and
cycling (rectal palpation should be performed).
- cattle must be in a fit and thrifty breeding
condition and on an adequate or increasing plane of nutrition.
- proper program planning and record keeping are
- if artificial insemination is being used it must be
performed by competent inseminators using high quality semen.
It is important to understand that estroPLAN
is effective only in animals with a mature corpus luteum (ovulation
must have occurred at least 5 days prior to treatment). This must be
considered when breeding is intended following a single estroPLAN
SAFETY AND TOXICITY:
At 50 and 100 times the recommended dose, mild side
effects may be detected in some cattle. These include increased
uneasiness, slight frothing, and milk let-down.
estroPLAN should not be administered
to a pregnant animal whose calf is not to be aborted.
For animal use only.
Women of child-bearing age, asthmatics, and persons with
bronchial and other respiratory problems should exercise extreme
caution when handling this product. In the early stages women may be
unaware of their pregnancies.
estroPLAN injection is readily
absorbed through the skin and may cause abortion and/or bronchospasms:
direct contact with the skin should therefore be avoided. Accidental
spillage on the skin should be washed off immediately with soap and
For a copy of the Material Safety Data Sheet (MSDS) call
To report adverse reactions call AgriLabs at
There is no effect on fertility following the single or
double dosage regimen when breeding occurs at induced estrus or at 72
and 96 hours post treatment. Conception rates may be lower than expected
in those fixed time breeding programs which omit the second
insemination (i.e. the insemination at or near 96 hours). This is
especially true if a fixed time insemination is used following a single estroPLAN injection.
As with all parenteral products, careful aseptic
techniques should be employed to decrease the possibility of post
injection bacterial infection. Antibiotic therapy should be employed at
the first sign of infection.
DOSAGE AND ADMINISTRATION:
2mL of estroPLAN injection (500 mcg
of cloprostenol) should be administered by INTRAMUSCULAR INJECTION for
all indications in both beef and dairy cattle.
1. Protect from light.
2. Store in carton.
3. Store at controlled room temperature 20°-25°C
20 mL multidose vials
ANADA 200-310, approved by FDA
Made in Australia
Manufactured by: Parnell Laboratories
(Aust) Pty Ltd, 4/476 Gardeners Road, Alexandria NSW 2015 Australia
Owner of the trademark estroPLAN
DISTRIBUTED BY: AGRI LABORATORIES, LTD.,
P.O. BOX 3103, ST. JOSEPH, MO 64503
© 2009 AgriLaboratories LTD. All rights reserved.
818 480 001
NAC No.: 10582250